Lin Lab

Haase C, Gustafsson K, Mei S, Yeh SC, Richter D, Milosevic J, Turcotte R, Kharchenko PV, Sykes DB, Scadden DT, Lin CP

Image-seq: spatially resolved single-cell sequencing guided by in situ and in vivo imaging.
Nat Methods. 2022;19(12):1622-1633 - PMID: 36424441 - PMCID: PMC9718684 - DOI: 10.1038/s41592-022-01673-2

Man CH, Mercier FE, Liu N, Dong W, Stephanopoulos G, Jiang L, Jung Y, Lin CP, Leung AYH, Scadden DT

Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and malignant cell growth.
Blood. 2022;139(4):502-522 - PMID: 34610101 - PMCID: PMC8796654 - DOI: 10.1182/blood.2021011563

Obaid G, Bano S, Thomsen H, Callaghan S, Shah N, Swain JWR, Jin W, Ding X, Cameron CG, McFarland SA, Wu J, Vangel M, Stoilova-McPhie S, Zhao J, Mino-Kenudson M, Lin C, Hasan T

Remediating Desmoplasia with EGFR-Targeted Photoactivable Multi-Inhibitor Liposomes Doubles Overall Survival in Pancreatic Cancer.
Adv Sci (Weinh). 2022;9(24):e2104594 - PMID: 35748165 - PMCID: PMC9404396 - DOI: 10.1002/advs.202104594

Bernstein L, Ramier A, Wu J, Aiello VD, Béland MJ, Lin CP, Yun SH

Ultrahigh resolution spectral-domain optical coherence tomography using the 1000-1600 nm spectral band.
Biomed Opt Express. 2022;13(4):1939-1947 - PMID: 35519264 - PMCID: PMC9045918 - DOI: 10.1364/BOE.443654

Pulous FE, Cruz-Hernández JC, Yang C, Kaya Ζ, Paccalet A, Wojtkiewicz G, Capen D, Brown D, Wu JW, Schloss MJ, Vinegoni C, Richter D, Yamazoe M, Hulsmans M, Momin N, Grune J, Rohde D, McAlpine CS, Panizzi P, Weissleder R, Kim DE, Swirski FK, Lin CP, Moskowitz MA, Nahrendorf M

Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis.
Nat Neurosci. 2022;25(5):567-576 - PMID: 35501382 - PMCID: PMC9081225 - DOI: 10.1038/s41593-022-01060-2
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