Guillermo Tearney, MD, PhD
Read BioDr. Tearney's research interests are focused on the development and clinical validation of non-invasive, high-resolution optical imaging methods for disease diagnosis. Dr. Tearney's lab was the first to perform human imaging in the coronary arteries and gastrointestinal tract in vivo with Optical Coherence Tomography (OCT), which provides cross-sectional images of tissue architectural microstructure at a resolution of 10 μm. He has also conducted many of the seminal studies validating OCT and is considered an expert on OCT image interpretation. Recently, Dr. Tearney's lab has invented a next generation OCT technology, termed μOCT, which has a resolution of 1 μm and is capable of imaging cells and sub cellular structures in the coronary wall. Dr. Tearney has also developed several other technologies, including a confocal endomicroscope capable of imaging the entire esophagus, an ultraminiature three-dimensional endoscope, a highly efficient form of near field scanning optical microscopy (NSOM), and novel fluorescence spectroscopy and multimodality imaging techniques. Dr. Tearney is co-editor of The Handbook of Optical Coherence Tomography and has written over 200 peer-reviewed publications, including papers that have been highlighted on the covers of Science, Nature Medicine, Circulation, Gastroenterology, and Journal of American College of Cardiology.
Dr. Tearney's work extends beyond his laboratory at MGH, many of his technologies are being produced commercially and he has founded the International Working Group on Intracoronary OCT Standardization and Validation, a group that is dedicated to establishing standards to ensure the widespread adoption of this imaging technology.
Group Website
For more information, please visit the Tearney Lab website:
www.tearneylab.org
Recent Publications
Schulz-Hildebrandt H, Gardecki JA, Miller T, Avila-Wallace M, Villareyna-Lopez E, Tearney G
Phase-sensitive dynamic micro-optical coherence tomography for high-speed intracellular motion imaging. Opt Lett. 2025;50(15):4734-4737 - PMID: 40751978 - DOI: 10.1364/OL.563024Rauschendorfer P, Thrapp A, Srinivas A, Carleton R, Mauskapf A, Griffin KN, Ntziachristos V, Tearney GJ, Jaffer FA
High-Speed Intravascular Near-infrared Fluorescence-Ultrasound Imaging In Vivo. IEEE Trans Biomed Eng. 2025;PP:ePub - PMID: 40742867 - DOI: 10.1109/TBME.2025.3594136Batts S, Pham N, Tearney G, Stankovic KM
The State of High-Resolution Imaging of the Human Inner Ear: A Look Into the Black Box. Adv Sci (Weinh). 2025;12(28):e00556 - PMID: 40470704 - PMCID: PMC12302556 - DOI: 10.1002/advs.202500556Otuya DO, Farrokhi H, Verma Y, Dong J, Choy P, Kumar A, Shore RE, Zemlok SK, Sevieri E, Schellenberg M, Spicer G, Lopez DR, Osman HA, Gardecki JA, Kyrollos Kelada AAF, Gao AH, Chung A, Grant CN, Bhat NGM, Rosenberg M, Jacobson BC, Nishioka NS, Colson Y, Tearney GJ
A thin cryobiopsy device compatible with transnasal endoscopy for the gastrointestinal tract. Sci Transl Med. 2025;17(796):eado9609 - PMID: 40305575 - DOI: 10.1126/scitranslmed.ado9609Araki M, Park SJ, Dauerman HL, Uemura S, Kim JS, Di Mario C, Johnson TW, Guagliumi G, Kastrati A, Joner M, Holm NR, Alfonso F, Wijns W, Adriaenssens T, Nef H, Rioufol G, Amabile N, Souteyrand G, Meneveau N, Gerbaud E, Opolski MP, Gonzalo N, Tearney GJ, Bouma B, Aguirre AD, Mintz GS, Stone GW, Bourantas CV, Räber L, Gili S, Mizuno K, Kimura S, Shinke T, Hong MK, Jang Y, Cho JM, Yan BP, Porto I, Niccoli G, Montone RA, Thondapu V, Papafaklis MI, Michalis LK, Reynolds H, Saw J, Libby P, Weisz G, Iannaccone M, Gori T, Toutouzas K, Yonetsu T, Minami Y, Takano M, Raffel OC, Kurihara O, Soeda T, Sugiyama T, Kim HO, Lee T, Higuma T, Nakajima A, Yamamoto E, Bryniarski KL, Di Vito L, Vergallo R, Fracassi F, Russo M, Seegers LM, McNulty I, Park S, Feldman M, Escaned J, Prati F, Arbustini E, Pinto FJ, Waksman R, Garcia-Garcia HM, Maehara A, Ali Z, Finn AV, Virmani R, Kini AS, Daemen J, Kume T, Hibi K, Tanaka A, Akasaka T, Kubo T, Yasuda S, Croce K, Granada JF, Lerman A, Prasad A, Regar E, Saito Y, Sankardas MA, Subban V, Weissman NJ, Chen Y, Yu B, Nicholls SJ, Barlis P, West NEJ, Arbab-Zadeh A, Ye JC, Dijkstra J, Lee H, Narula J, Crea F, Nakamura S, Kakuta T, Fujimoto J, Fuster V, Jang IK
Optical coherence tomography in coronary atherosclerosis assessment and intervention. Nat Rev Cardiol. 2022;19(10):684-703 - PMID: 35449407 - PMCID: PMC9982688 - DOI: 10.1038/s41569-022-00687-9- More publications ...
