Seemantini Nadkarni, PhD
Read BioDr. Seemantini Nadkarni is an Associate Professor of Dermatology at Harvard Medical School, and directs her laboratory at the Wellman Center for Photomedicine at Massachusetts General Hospital. She received her PhD in Medical Biophysics from the University of Western Ontario, Canada. Her doctoral research focused on three-dimensional ultrasound approaches with applications in echocardiography and intracoronary imaging. Following her doctoral work, she completed her post-doctoral fellowship as an NSERC scholar at the Wellman Center for Photomedicine, where she continued her research on intracoronary imaging, and focused on exploring optical strategies to evaluate tissue biomechanics and microstructure. Her research encompasses both fundamental and translational areas of research, primarily focused on the invention and investigation of novel optical technologies for applications in Hematology, Cardiology, cancer research and in vitro diagnostics. The research initiatives in the Nadkarni lab span the investigation of novel optical methods using multimodal approaches to detect unstable plaque, the development of hand-held optical sensors for whole blood testing at the point-of-care and development of new imaging strategies to quantify the micromechanical properties of the tumor extracellular matrix. In addition, the group is developing optical approaches and endoscopic probes for intra-luminal imaging of soft tissue biomechanics for a variety of clinical applications.
For more information about the Nadkarni laboratory please visit nadkarnilab.mgh.harvard.edu.
Selected Publications
Evans CL, Xie XS
Coherent anti-stokes Raman scattering microscopy: chemical imaging for biology and medicine. Annu Rev Anal Chem (Palo Alto Calif). 2008;1:883-909 - PMID: 20636101 - DOI: 10.1146/annurev.anchem.1.031207.112754Allouche J, Rachmin I, Adhikari K, Pardo LM, Lee JH, McConnell AM, Kato S, Fan S, Kawakami A, Suita Y, Wakamatsu K, Igras V, Zhang J, Navarro PP, Lugo CM, Noonan HR, Christie KA, Itin K, Mujahid N, Lo JA, Won CH, Evans CL, Weng QY, Wang H, Osseiran S, Lovas A, Németh I, Cozzio A, Navarini AA, Hsiao JJ, Nguyen N, Kemény LV, Iliopoulos O, Berking C, Ruzicka T, Gonzalez-José R, Bortolini MC, Canizales-Quinteros S, Acuna-Alonso V, Gallo C, Poletti G, Bedoya G, Rothhammer F, Ito S, Schiaffino MV, Chao LH, Kleinstiver BP, Tishkoff S, Zon LI, Nijsten T, Ruiz-Linares A, Fisher DE, Roider E
NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism. Cell. 2021;184(16):4268-4283.e20 - PMID: 34233163 - PMCID: PMC8349839 - DOI: 10.1016/j.cell.2021.06.022Marks H, Bucknor A, Roussakis E, Nowell N, Kamali P, Cascales JP, Kazei D, Lin SJ, Evans CL
A paintable phosphorescent bandage for postoperative tissue oxygen assessment in DIEP flap reconstruction. Sci Adv. 2020;6(51):ePub - PMID: 33355131 - PMCID: PMC11206211 - DOI: 10.1126/sciadv.abd1061Cascales JP, Roussakis E, Witthauer L, Goss A, Li X, Chen Y, Marks HL, Evans CL
Wearable device for remote monitoring of transcutaneous tissue oxygenation. Biomed Opt Express. 2020;11(12):6989-7002 - PMID: 33408975 - PMCID: PMC7747925 - DOI: 10.1364/BOE.408850Roussakis E, Li Z, Nowell NH, Nichols AJ, Evans CL
Bright, "Clickable" Porphyrins for the Visualization of Oxygenation under Ambient Light. Angew Chem Int Ed Engl. 2015;54(49):14728-31 - PMID: 26510549 - PMCID: PMC4715754 - DOI: 10.1002/anie.201506847Roussakis E, Li Z, Nichols AJ, Evans CL
Oxygen-Sensing Methods in Biomedicine from the Macroscale to the Microscale. Angew Chem Int Ed Engl. 2015;54(29):8340-62 - PMID: 26084034 - DOI: 10.1002/anie.201410646- More publications ...
