Lin Lab

Wu Q, Zhang J, Kumar S, Shen S, Kincaid M, Johnson CB, Zhang YS, Turcotte R, Alt C, Ito K, Homan S, Sherman BE, Shao TY, Slaughter A, Weinhaus B, Song B, Filippi MD, Grimes HL, Lin CP, Ito K, Way SS, Kofron JM, Lucas D

Resilient anatomy and local plasticity of naive and stress haematopoiesis.
Nature. 2024;627(8005):839-846 - PMID: 38509363 - PMCID: PMC10972750 - DOI: 10.1038/s41586-024-07186-6

Pessoa Rodrigues C, Collins JM, Yang S, Martinez C, Kim JW, Lama C, Nam AS, Alt C, Lin C, Zon LI

Transcripts of repetitive DNA elements signal to block phagocytosis of hematopoietic stem cells.
Science. 2024;385(6714):eadn1629 - PMID: 39264994 - PMCID: PMC12012832 - DOI: 10.1126/science.adn1629

Bonora M, Morganti C, van Gastel N, Ito K, Calura E, Zanolla I, Ferroni L, Zhang Y, Jung Y, Sales G, Martini P, Nakamura T, Lasorsa FM, Finkel T, Lin CP, Zavan B, Pinton P, Georgakoudi I, Romualdi C, Scadden DT, Ito K

A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate.
Cell Stem Cell. 2024;31(3):359-377.e10 - PMID: 38458178 - PMCID: PMC10957094 - DOI: 10.1016/j.stem.2024.02.004

Conedera FM, Kokona D, Zinkernagel MS, Stein JV, Lin CP, Alt C, Enzmann V

Macrophages coordinate immune response to laser-induced injury via extracellular traps.
J Neuroinflammation. 2024;21(1):68 - PMID: 38500151 - PMCID: PMC10949579 - DOI: 10.1186/s12974-024-03064-0

Aldawood ZA, Mancinelli L, Geng X, Yeh SA, Di Carlo R, C Leite T, Gustafson J, Wilk K, Yozgatian J, Garakani S, Bassir SH, Cunningham ML, Lin CP, Intini G

Expansion of the sagittal suture induces proliferation of skeletal stem cells and sustains endogenous calvarial bone regeneration.
Proc Natl Acad Sci U S A. 2023;120(16):e2120826120 - PMID: 37040407 - PMCID: PMC10120053 - DOI: 10.1073/pnas.2120826120

Conedera FM, Runnels JM, Stein JV, Alt C, Enzmann V, Lin CP

Assessing the role of T cells in response to retinal injury to uncover new therapeutic targets for the treatment of retinal degeneration.
J Neuroinflammation. 2023;20(1):206 - PMID: 37689689 - PMCID: PMC10492418 - DOI: 10.1186/s12974-023-02867-x

Bagramyan A, Lin CP

Miniaturized microscope for non-invasive imaging of leukocyte-endothelial interaction in human microcirculation.
Sci Rep. 2023;13(1):17881 - PMID: 37857684 - PMCID: PMC10587353 - DOI: 10.1038/s41598-023-45018-1

Haase C, Richter D, Lin CP

Laser Micromachining of Bone as a Tool for Studying Bone Marrow Biology.
Methods Mol Biol. 2023;2567:163-180 - PMID: 36255701 - PMCID: PMC10287113 - DOI: 10.1007/978-1-0716-2679-5_11

Shah VS, Hou J, Vinarsky V, Xu J, Surve MV, Lin CP, Rajagopal J

Autofluorescence imaging permits label-free cell type assignment and reveals the dynamic formation of airway secretory cell associated antigen passages (SAPs).
Elife. 2023;12:ePub - PMID: 36994985 - PMCID: PMC10154029 - DOI: 10.7554/eLife.84375

Jiménez-Dinamarca I, Prado Y, Tapia P, Gatica S, Alt C, Lin CP, Reyes-Martínez C, Feijóo CG, Aravena C, González-Canacer A, Correa S, Varela D, Cabello-Verrugio C, Simon F

Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis.
Biol Res. 2023;56(1):8 - PMID: 36869357 - PMCID: PMC9983216 - DOI: 10.1186/s40659-023-00419-4

Jiménez-Dinamarca I, Prado Y, Tapia P, Gatica S, Alt C, Lin CP, Reyes-Martínez C, Feijóo CG, Aravena C, González-Canacer A, Correa S, Varela D, Cabello-Verrugio C, Simon F

Correction: Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis.
Biol Res. 2023;56(1):24 - PMID: 37165417 - PMCID: PMC10173557 - DOI: 10.1186/s40659-023-00433-6

Haase C, Gustafsson K, Mei S, Yeh SC, Richter D, Milosevic J, Turcotte R, Kharchenko PV, Sykes DB, Scadden DT, Lin CP

Image-seq: spatially resolved single-cell sequencing guided by in situ and in vivo imaging.
Nat Methods. 2022;19(12):1622-1633 - PMID: 36424441 - PMCID: PMC9718684 - DOI: 10.1038/s41592-022-01673-2

Man CH, Mercier FE, Liu N, Dong W, Stephanopoulos G, Jiang L, Jung Y, Lin CP, Leung AYH, Scadden DT

Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and malignant cell growth.
Blood. 2022;139(4):502-522 - PMID: 34610101 - PMCID: PMC8796654 - DOI: 10.1182/blood.2021011563

Obaid G, Bano S, Thomsen H, Callaghan S, Shah N, Swain JWR, Jin W, Ding X, Cameron CG, McFarland SA, Wu J, Vangel M, Stoilova-McPhie S, Zhao J, Mino-Kenudson M, Lin C, Hasan T

Remediating Desmoplasia with EGFR-Targeted Photoactivable Multi-Inhibitor Liposomes Doubles Overall Survival in Pancreatic Cancer.
Adv Sci (Weinh). 2022;9(24):e2104594 - PMID: 35748165 - PMCID: PMC9404396 - DOI: 10.1002/advs.202104594

Bernstein L, Ramier A, Wu J, Aiello VD, Béland MJ, Lin CP, Yun SH

Ultrahigh resolution spectral-domain optical coherence tomography using the 1000-1600 nm spectral band.
Biomed Opt Express. 2022;13(4):1939-1947 - PMID: 35519264 - PMCID: PMC9045918 - DOI: 10.1364/BOE.443654

Turcotte R, Wu JW, Lin CP

Intravital multiphoton photoconversion with a cell membrane dye.
J Biophotonics. 2016;10(2):206-210 - PMID: 27433967 - DOI: 10.1002/jbio.201600077

Kong L, Tang J, Little JP, Yu Y, Lämmermann T, Lin CP, Germain RN, Cui M

Continuous volumetric imaging via an optical phase-locked ultrasound lens.
Nat Methods. 2015;12(8):759-62 - PMID: 26167641 - PMCID: PMC4551496 - DOI: 10.1038/nmeth.3476

Stein-Merlob AF, Kessinger CW, Erdem SS, Zelada H, Hilderbrand SA, Lin CP, Tearney GJ, Jaff MR, Reed GL, Henke PK, McCarthy JR, Jaffer FA

Blood Accessibility to Fibrin in Venous Thrombosis is Thrombus Age-Dependent and Predicts Fibrinolytic Efficacy: An In Vivo Fibrin Molecular Imaging Study.
Theranostics. 2015;5(12):1317-27 - PMID: 26516370 - PMCID: PMC4615735 - DOI: 10.7150/thno.12494

Aceto N, Bardia A, Miyamoto DT, Donaldson MC, Wittner BS, Spencer JA, Yu M, Pely A, Engstrom A, Zhu H, Brannigan BW, Kapur R, Stott SL, Shioda T, Ramaswamy S, Ting DT, Lin CP, Toner M, Haber DA, Maheswaran S

Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis.
Cell. 2014;158(5):1110-1122 - PMID: 25171411 - PMCID: PMC4149753 - DOI: 10.1016/j.cell.2014.07.013

Saez B, Ferraro F, Yusuf RZ, Cook CM, Yu VW, Pardo-Saganta A, Sykes SM, Palchaudhuri R, Schajnovitz A, Lotinun S, Lymperi S, Mendez-Ferrer S, Toro RD, Day R, Vasic R, Acharya SS, Baron R, Lin CP, Yamaguchi Y, Wagers AJ, Scadden DT

Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning.
Blood. 2014;124(19):2937-47 - PMID: 25202142 - PMCID: PMC4224192 - DOI: 10.1182/blood-2014-08-593426

Roussakis E, Spencer JA, Lin CP, Vinogradov SA

Two-photon antenna-core oxygen probe with enhanced performance.
Anal Chem. 2014;86(12):5937-45 - PMID: 24848643 - PMCID: PMC4066907 - DOI: 10.1021/ac501028m

Alt C, Runnels JM, Mortensen LJ, Zaher W, Lin CP

In vivo imaging of microglia turnover in the mouse retina after ionizing radiation and dexamethasone treatment.
Invest Ophthalmol Vis Sci. 2014;55(8):5314-9 - PMID: 25082884 - DOI: 10.1167/iovs.14-14254

Turcotte R, Alt C, Mortensen LJ, Lin CP

Characterization of multiphoton microscopy in the bone marrow following intravital laser osteotomy.
Biomed Opt Express. 2014;5(10):3578-88 - PMID: 25360374 - PMCID: PMC4206326 - DOI: 10.1364/BOE.5.003578

Mortensen LJ, Alt C, Turcotte R, Masek M, Liu TM, Côté DC, Xu C, Intini G, Lin CP

Femtosecond laser bone ablation with a high repetition rate fiber laser source.
Biomed Opt Express. 2014;6(1):32-42 - PMID: 25657872 - PMCID: PMC4317121 - DOI: 10.1364/BOE.6.000032

Hara T, Bhayana B, Thompson B, Kessinger CW, Khatri A, McCarthy JR, Weissleder R, Lin CP, Tearney GJ, Jaffer FA

Molecular imaging of fibrin deposition in deep vein thrombosis using fibrin-targeted near-infrared fluorescence.
JACC Cardiovasc Imaging. 2012;5(6):607-15 - PMID: 22698530 - PMCID: PMC3376390 - DOI: 10.1016/j.jcmg.2012.01.017

Pitsillides CM, Runnels JM, Spencer JA, Zhi L, Wu MX, Lin CP

Cell labeling approaches for fluorescence-based in vivo flow cytometry.
Cytometry A. 2011;79(10):758-65 - PMID: 21905206 - PMCID: PMC3686107 - DOI: 10.1002/cyto.a.21125

Kim P, Puoris'haag M, Côté D, Lin CP, Yun SH

In vivo confocal and multiphoton microendoscopy.
J Biomed Opt. 2008;13(1):010501 - PMID: 18315346 - PMCID: PMC2752311 - DOI: 10.1117/1.2839043

Framme C, Alt C, Schnell S, Sherwood M, Brinkmann R, Lin CP

Selective targeting of the retinal pigment epithelium in rabbit eyes with a scanning laser beam.
Invest Ophthalmol Vis Sci. 2007;48(4):1782-92 - PMID: 17389512 - DOI: 10.1167/iovs.06-0797

Alt C, Veilleux I, Lee H, Pitsillides CM, Côté D, Lin CP

Retinal flow cytometer.
Opt Lett. 2007;32(23):3450-2 - PMID: 18059963 - PMCID: PMC2794483 - DOI: 10.1364/ol.32.003450

Evans CL, Potma EO, Puoris'haag M, Côté D, Lin CP, Xie XS

Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy.
Proc Natl Acad Sci U S A. 2005;102(46):16807-12 - PMID: 16263923 - PMCID: PMC1283840 - DOI: 10.1073/pnas.0508282102

Pitsillides CM, Joe EK, Wei X, Anderson RR, Lin CP

Selective cell targeting with light-absorbing microparticles and nanoparticles.
Biophys J. 2003;84(6):4023-32 - PMID: 12770906 - PMCID: PMC1302982 - DOI: 10.1016/S0006-3495(03)75128-5

Wei X, Runnels JM, Lin CP

Selective uptake of indocyanine green by reticulocytes in circulation.
Invest Ophthalmol Vis Sci. 2003;44(10):4489-96 - PMID: 14507897 - PMCID: PMC2830078 - DOI: 10.1167/iovs.03-0041

Bogdanov AA, Lin CP, Simonova M, Matuszewski L, Weissleder R

Cellular activation of the self-quenched fluorescent reporter probe in tumor microenvironment.
Neoplasia. 2002;4(3):228-36 - PMID: 11988842 - PMCID: PMC1531696 - DOI: 10.1038/sj.neo.7900238
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