Hasan Lab

Ilina A, Ochoa Mendoza MI, Cao X, Hasan T, Pogue BW

ALA-based photodynamic priming in murine skin increases blood flow and oxygenation.
J Biomed Opt. 2025;30(Suppl 3):S34106 - PMID: 40949529 - PMCID: PMC12433272 - DOI: 10.1117/1.JBO.30.S3.S34106

Paul A, Nguyen C, Hasan T, Mallidi S

Reduction of photobleaching effects in photoacoustic imaging using noise agnostic, platform-flexible deep-learning methods.
J Biomed Opt. 2025;30(Suppl 3):S34102 - PMID: 40443946 - PMCID: PMC12118878 - DOI: 10.1117/1.JBO.30.S3.S34102

Ichikawa M, Akimoto J, Mallidi S, Wakimoto H, Kohno M, Hasan T

Photodynamic therapy using talaporfin sodium and semiconductor laser induces dose and time dependent cytocidal effect for human glioma derived stem cells.
Photodiagnosis Photodyn Ther. 2025;:105215 - PMID: 40915515 - DOI: 10.1016/j.pdpdt.2025.105215

Maytin EV, Zeitouni NC, Updyke A, Negrey JT, Shen AS, Heusinkveld LE, Mack JA, Hu B, Anand S, Maytin TA, Giostra L, Bullock T, Warren CB, Hasan T

High-dose oral Vitamin D in combination with photodynamic therapy can accelerate the clearance rate of basal cell carcinoma: A randomized clinical trial.
Photodiagnosis Photodyn Ther. 2025;55:104704 - PMID: 40633744 - DOI: 10.1016/j.pdpdt.2025.104704

Maytin EV, Zeitouni NC, Updyke A, Negrey J, Shen AS, Heusinkveld LE, Mack JA, Hu B, Anand S, Maytin TA, Giostra L, Warren CB, Hasan T

A Clinical Trial to Determine the Impact of Tumor Size, Histological Subtype, and Vitamin D Status on the Therapeutic Response of Basal Cell Carcinoma to Photodynamic Therapy.
medRxiv. 2025;:ePub - PMID: 39974008 - PMCID: PMC11838694 - DOI: 10.1101/2025.01.30.25321144

De Silva P, Saad MA, Swain JWR, Mai Z, Kidd MD, Choe JJ, Camargo AP, Anand S, Chandrasekhara V, Pogue BW, Wang KK, Spring BQ, Maytin EV, Hasan T

Photodynamic priming with red light triggers adaptive immune responses in a pancreatic cancer mouse model.
J Photochem Photobiol B. 2025;265:113126 - PMID: 40007355 - PMCID: PMC11895200 - DOI: 10.1016/j.jphotobiol.2025.113126

Petusseau AF, Ochoa M, Reed M, Doyley MM, Hasan T, Bruza P, Pogue BW

Pressure-enhanced sensing of tissue oxygenation via endogenous porphyrin: Implications for dynamic visualization of cancer in surgery.
Proc Natl Acad Sci U S A. 2024;121(34):e2405628121 - PMID: 39141355 - PMCID: PMC11348300 - DOI: 10.1073/pnas.2405628121

Bhandari C, Moffat A, Shah N, Khan A, Quaye M, Fakhry J, Soma S, Nguyen A, Eroy M, Malkoochi A, Brekken R, Hasan T, Ferruzzi J, Obaid G

PD-L1 Immune Checkpoint Targeted Photoactivable Liposomes (iTPALs) Prime the Stroma of Pancreatic Tumors and Promote Self-Delivery.
Adv Healthc Mater. 2024;13(19):e2304340 - PMID: 38324463 - PMCID: PMC11281872 - DOI: 10.1002/adhm.202304340

Viana Cabral F, Quilez Alburquerque J, Roberts HJ, Hasan T

Shedding Light on Chemoresistance: The Perspective of Photodynamic Therapy in Cancer Management.
Int J Mol Sci. 2024;25(7):ePub - PMID: 38612619 - PMCID: PMC11011502 - DOI: 10.3390/ijms25073811

Kulkarni MB, Reed MS, Cao X, García HA, Ochoa MI, Jiang S, Hasan T, Doyley MM, Pogue BW

Combined dual-channel fluorescence depth sensing of indocyanine green and protoporphyrin IX kinetics in subcutaneous murine tumors.
J Biomed Opt. 2024;30(Suppl 1):S13709 - PMID: 39559531 - PMCID: PMC11571966 - DOI: 10.1117/1.JBO.30.S1.S13709

Liu Y, Mensah SK, Farias S, Khan S, Hasan T, Celli JP

Efficacy of photodynamic therapy using 5-aminolevulinic acid-induced photosensitization is enhanced in pancreatic cancer cells with acquired drug resistance.
Photodiagnosis Photodyn Ther. 2024;50:104362 - PMID: 39395619 - PMCID: PMC11645186 - DOI: 10.1016/j.pdpdt.2024.104362

Coradi Tonon C, de Souza Rastelli AN, Bodahandi C, Ashraf S, Hasan T, Xu Q, Greer A, Lyons AM

Effect of treatment frequency on the efficacy of superhydrophobic antimicrobial photodynamic therapy of periodontitis in a wistar rat model.
Photochem Photobiol. 2024;101(3):592-608 - PMID: 39387243 - PMCID: PMC11982352 - DOI: 10.1111/php.14021

Zahid MU, Waguespack M, Harman RC, Kercher EM, Nath S, Hasan T, Rizvi I, Spring BQ, Enderling H

Fractionated photoimmunotherapy stimulates an anti-tumour immune response: an integrated mathematical and in vitro study.
Br J Cancer. 2024;131(8):1378-1386 - PMID: 39261715 - PMCID: PMC11473784 - DOI: 10.1038/s41416-024-02844-y

V Cabral F, Xu Q, Greer A, Lyons AM, Hasan T

Superhydrophobic Dressing for Singlet Oxygen Delivery in Antimicrobial Photodynamic Therapy against Multidrug-Resistant Bacterial Biofilms.
ACS Appl Bio Mater. 2024;7(9):6175-6185 - PMID: 39166743 - PMCID: PMC11409211 - DOI: 10.1021/acsabm.4c00733

Obaid G, Celli JP, Broekgaarden M, Bulin AL, Uusimaa P, Pogue B, Hasan T, Huang HC

Engineering photodynamics for treatment, priming and imaging.
Nat Rev Bioeng. 2024;2(9):752-769 - PMID: 39927170 - PMCID: PMC11801064 - DOI: 10.1038/s44222-024-00196-z

Saad MA, Allen D, Sweeney A, Xavierselvan M, Mallidi S, Hasan T

Temporal dynamics of fluorescence and photoacoustic signals of a Cetuximab-IRDye800 conjugate in EGFR-overexpressing tumors.
bioRxiv. 2024;:ePub - PMID: 39677759 - PMCID: PMC11642854 - DOI: 10.1101/2024.11.26.625469

Parikh KS, Fuleihan A, Acharya S, Sathi T, Hasan T, Yao KH, Yazdi Y

Health Care Innovation for Low-Resource Settings: The Value of Local Immersion and Partnership.
IEEE Pulse. 2024;15(1):9-14 - PMID: 38619927 - DOI: 10.1109/MPULS.2024.3370429

Anand S, Hasan T, Maytin EV

Treatment of nonmelanoma skin cancer with pro-differentiation agents and photodynamic therapy: Preclinical and clinical studies (Review).
Photochem Photobiol. 2024;100(6):1541-1560 - PMID: 38310633 - PMCID: PMC11297983 - DOI: 10.1111/php.13914

Anand S, Shen A, Cheng CE, Chen J, Powers J, Rayman P, Diaz M, Hasan T, Maytin EV

Combination of vitamin D and photodynamic therapy enhances immune responses in murine models of squamous cell skin cancer.
Photodiagnosis Photodyn Ther. 2024;45:103983 - PMID: 38281610 - PMCID: PMC11197882 - DOI: 10.1016/j.pdpdt.2024.103983

Spring BQ, Watanabe K, Ichikawa M, Mallidi S, Matsudaira T, Timerman D, Swain JWR, Mai Z, Wakimoto H, Hasan T

Red light-activated depletion of drug-refractory glioblastoma stem cells and chemosensitization of an acquired-resistant mesenchymal phenotype.
Photochem Photobiol. 2024;101(1):215-229 - PMID: 38922889 - PMCID: PMC11664018 - DOI: 10.1111/php.13985

Timilsina S, Saad MA, Lang RT, Hasan T, Spring BQ

Methods for assessing and removing non-specific photoimmunotherapy damage in patient-derived tumor cell culture models.
Photochem Photobiol. 2024;101(1):4-20 - PMID: 38728432 - PMCID: PMC11550265 - DOI: 10.1111/php.13957

Bano S, Alburquerque JQ, Roberts HJ, Pang S, Huang HC, Hasan T

Minocycline and photodynamic priming significantly improve chemotherapy efficacy in heterotypic spheroids of pancreatic ductal adenocarcinoma.
J Photochem Photobiol B. 2024;255:112910 - PMID: 38663337 - PMCID: PMC11088523 - DOI: 10.1016/j.jphotobiol.2024.112910

Liang BJ, Pang S, Perttila R, Ma CH, Srivastava P, Gaitan B, Sorrin AJ, Fadul N, Rahman I, Yl Formula See Text Niemi Z, Roque DM, Hasan T, Uusimaa P, Huang HC

Fluorescence-guided photoimmunotherapy using targeted nanotechnology and ML7710 to manage peritoneal carcinomatosis.
Sci Adv. 2023;9(36):eadi3441 - PMID: 37672582 - PMCID: PMC10482332 - DOI: 10.1126/sciadv.adi3441

Tonon CC, de Souza Rastelli AN, Bodahandi C, Ghosh G, Hasan T, Xu Q, Greer A, Lyons AM

Superhydrophobic Tipped Antimicrobial Photodynamic Therapy Device for the In Vivo Treatment of Periodontitis Using a Wistar Rat Model.
ACS Appl Mater Interfaces. 2023;15(43):50083-50094 - PMID: 37862708 - PMCID: PMC10800031 - DOI: 10.1021/acsami.3c12820

Saad MA, Pawle R, Selfridge S, Contreras L, Xavierselvan M, Nguyen CD, Mallidi S, Hasan T

Optimizing Axial and Peripheral Substitutions in Si-Centered Naphthalocyanine Dyes for Enhancing Aqueous Solubility and Photoacoustic Signal Intensity.
Int J Mol Sci. 2023;24(3):ePub - PMID: 36768560 - PMCID: PMC9916426 - DOI: 10.3390/ijms24032241

Saad MA, Grimaldo-Garcia S, Sweeney A, Mallidi S, Hasan T

Dual-Function Antibody Conjugate-Enabled Photoimmunotherapy Complements Fluorescence and Photoacoustic Imaging of Head and Neck Cancer Spheroids.
Bioconjug Chem. 2023;35(1):51-63 - PMID: 38128912 - PMCID: PMC10797594 - DOI: 10.1021/acs.bioconjchem.3c00406

Khan S, Song B, Mallidi S, Li S, Liu H, Bilal Hussain MA, Siddiqui S, Khan AP, Akhtar K, Siddiqui SA, Hasan SA, Hopper C, Bown SG, Liang R, Hasan T, Celli JP

Clinical assessment of a low-cost, hand-held, smartphone-attached intraoral imaging probe for 5-aminolevulinic acid photodynamic therapy monitoring and guidance.
J Biomed Opt. 2023;28(8):082809 - PMID: 37483565 - PMCID: PMC10362156 - DOI: 10.1117/1.JBO.28.8.082809

Shimizu K, Kahramanian A, Jabbar MADA, Turna Demir F, Gokyer D, Uthamacumaran A, Rajan A, Saad MA, Gorham J, Wakimoto H, Martuza RL, Rabkin SD, Hasan T, Wakimoto H

Photodynamic augmentation of oncolytic virus therapy for central nervous system malignancies.
Cancer Lett. 2023;572:216363 - PMID: 37619813 - PMCID: PMC10529118 - DOI: 10.1016/j.canlet.2023.216363

Samkoe KS, Sexton K, Tichauer KM, Hextrum SK, Pardesi O, Davis SC, O'Hara JA, Hoopes PJ, Hasan T, Pogue BW

Correction: High Vascular Delivery of EGF, but Low Receptor Binding Rate Is Observed in AsPC-1 Tumors as Compared to Normal Pancreas.
Mol Imaging Biol. 2023;25(6):1150 - PMID: 37789104 - DOI: 10.1007/s11307-023-01862-1

Bullock TA, Mack JA, Negrey J, Kaw U, Hu B, Anand S, Hasan T, Warren CB, Maytin EV

Significant Association of Poly-A and Fok1 Polymorphic Alleles of the Vitamin D Receptor with Vitamin D Serum Levels and Incidence of Squamous Cutaneous Neoplasia.
J Invest Dermatol. 2023;143(8):1538-1547 - PMID: 36813159 - PMCID: PMC10439970 - DOI: 10.1016/j.jid.2023.01.028

Bhandari C, Moffat A, Fakhry J, Malkoochi A, Nguyen A, Trinh B, Hoyt K, Story MD, Hasan T, Obaid G

A single photodynamic priming protocol augments delivery of ⍺-PD-L1 mAbs and induces immunogenic cell death in head and neck tumors.
Photochem Photobiol. 2023;100(6):1647-1658 - PMID: 37818742 - PMCID: PMC11006828 - DOI: 10.1111/php.13865

Obaid G, Eroy M, Zhao J, Bano S, Mino-Kenudson M, Hasan T

Immunofluorescence profiling of collagen subtypes is a predictor of treatment outcomes in pancreatic cancer.
J Photochem Photobiol B. 2023;250:112811 - PMID: 38000171 - PMCID: PMC10841621 - DOI: 10.1016/j.jphotobiol.2023.112811

Obaid G, Bano S, Thomsen H, Callaghan S, Shah N, Swain JWR, Jin W, Ding X, Cameron CG, McFarland SA, Wu J, Vangel M, Stoilova-McPhie S, Zhao J, Mino-Kenudson M, Lin C, Hasan T

Remediating Desmoplasia with EGFR-Targeted Photoactivable Multi-Inhibitor Liposomes Doubles Overall Survival in Pancreatic Cancer.
Adv Sci (Weinh). 2022;9(24):e2104594 - PMID: 35748165 - PMCID: PMC9404396 - DOI: 10.1002/advs.202104594

Bhandari C, Fakhry J, Eroy M, Song JJ, Samkoe K, Hasan T, Hoyt K, Obaid G

Towards Photodynamic Image-Guided Surgery of Head and Neck Tumors: Photodynamic Priming Improves Delivery and Diagnostic Accuracy of Cetuximab-IRDye800CW.
Front Oncol. 2022;12:853660 - PMID: 35837101 - PMCID: PMC9273965 - DOI: 10.3389/fonc.2022.853660

Early S, Saad MA, Mallidi S, Mansour A, Seist R, Hasan T, Stankovic KM

A fluorescent photoimmunoconjugate for imaging of cholesteatoma.
Sci Rep. 2022;12(1):19905 - PMID: 36402793 - PMCID: PMC9675863 - DOI: 10.1038/s41598-022-22072-9

Obaid G, Mai Z, Hasan T

Orthotopic Models of Pancreatic Cancer to Study PDT.
Methods Mol Biol. 2022;2451:163-173 - PMID: 35505017 - PMCID: PMC10515273 - DOI: 10.1007/978-1-0716-2099-1_12

Obaid G, Hasan T

Subcutaneous Xenograft Models for Studying PDT In Vivo.
Methods Mol Biol. 2022;2451:127-149 - PMID: 35505015 - PMCID: PMC10516195 - DOI: 10.1007/978-1-0716-2099-1_10

Nath S, Pigula M, Hasan T, Rizvi I

A Perfusion Model to Evaluate Response to Photodynamic Therapy in 3D Tumors.
Methods Mol Biol. 2022;2451:49-58 - PMID: 35505009 - DOI: 10.1007/978-1-0716-2099-1_4

Bulin AL, Hasan T

Spatiotemporal Tracking of Different Cell Populations in Cancer Organoid Models for Investigations on Photodynamic Therapy.
Methods Mol Biol. 2022;2451:81-90 - PMID: 35505012 - DOI: 10.1007/978-1-0716-2099-1_7

Bulin AL, Broekgaarden M, Hasan T

Analysis of Treatment Effects on Structurally Complex Microtumor Cultures Using a Comprehensive Image Analysis Procedure.
Methods Mol Biol. 2022;2451:59-70 - PMID: 35505010 - DOI: 10.1007/978-1-0716-2099-1_5

Broekgaarden M, Bulin AL, Hasan T

High-Throughput Examination of Therapy-Induced Alterations in Redox Metabolism in Spheroid and Microtumor Models.
Methods Mol Biol. 2022;2451:71-80 - PMID: 35505011 - DOI: 10.1007/978-1-0716-2099-1_6

Kessel D, Gomer CJ, Hasan T

Paul K Strudler: The Oracle of RAD.
Photochem Photobiol. 2022;98(5):985-986 - PMID: 36114819 - DOI: 10.1111/php.13670

Feng Y, Tonon CC, Hasan T

Dramatic destruction of methicillin-resistant Staphylococcus aureus infections with a simple combination of amoxicillin and light-activated methylene blue.
J Photochem Photobiol B. 2022;235:112563 - PMID: 36099788 - DOI: 10.1016/j.jphotobiol.2022.112563

Bullock TA, Negrey J, Hu B, Warren CB, Hasan T, Maytin EV

Significant improvement of facial actinic keratoses after blue light photodynamic therapy with oral vitamin D pretreatment: An interventional cohort-controlled trial.
J Am Acad Dermatol. 2022;87(1):80-86 - PMID: 35314199 - PMCID: PMC9233022 - DOI: 10.1016/j.jaad.2022.02.067

Ashraf S, Khalid A, de Vos AL, Feng Y, Rohrbach P, Hasan T

Malaria Detection Accelerated: Combing a High-Throughput NanoZoomer Platform with a ParasiteMacro Algorithm.
Pathogens. 2022;11(10):ePub - PMID: 36297240 - PMCID: PMC9606851 - DOI: 10.3390/pathogens11101182

Anand S, Heusinkveld LE, Cheng CE, Lefatshe L, De Silva P, Hasan T, Maytin EV

Combination of 5-Fluorouracil with Photodynamic Therapy: Enhancement of Innate and Adaptive Immune Responses in a Murine Model of Actinic Keratosis†.
Photochem Photobiol. 2022;99(2):437-447 - PMID: 36039609 - PMCID: PMC10319084 - DOI: 10.1111/php.13706
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