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Sackstein R, Merzaban JS, Cain DW, Dagia NM, Spencer JA, Lin CP, Wohlgemuth R

Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone.
Nat Med. 2008;14(2):181-7 - PMID: 18193058 - DOI: 10.1038/nm1703

Dagia NM, Gadhoum SZ, Knoblauch CA, Spencer JA, Zamiri P, Lin CP, Sackstein R

G-CSF induces E-selectin ligand expression on human myeloid cells.
Nat Med. 2006;12(10):1185-90 - PMID: 16980970 - DOI: 10.1038/nm1470

King KR, Aguirre AD, Ye YX, Sun Y, Roh JD, Ng RP, Kohler RH, Arlauckas SP, Iwamoto Y, Savol A, Sadreyev RI, Kelly M, Fitzgibbons TP, Fitzgerald KA, Mitchison T, Libby P, Nahrendorf M, Weissleder R

IRF3 and type I interferons fuel a fatal response to myocardial infarction.
Nat Med. 2017;23(12):1481-1487 - PMID: 29106401 - PMCID: PMC6477926 - DOI: 10.1038/nm.4428

Fan Z, Spencer JA, Lu Y, Pitsillides CM, Singh G, Kim P, Yun SH, Toxavidis V, Strom TB, Lin CP, Koulmanda M

In vivo tracking of 'color-coded' effector, natural and induced regulatory T cells in the allograft response.
Nat Med. 2010;16(6):718-22 - PMID: 20495571 - PMCID: PMC2894571 - DOI: 10.1038/nm.2155

Heidt T, Sager HB, Courties G, Dutta P, Iwamoto Y, Zaltsman A, von Zur Muhlen C, Bode C, Fricchione GL, Denninger J, Lin CP, Vinegoni C, Libby P, Swirski FK, Weissleder R, Nahrendorf M

Chronic variable stress activates hematopoietic stem cells.
Nat Med. 2014;20(7):754-758 - PMID: 24952646 - PMCID: PMC4087061 - DOI: 10.1038/nm.3589

Itkin T, Gur-Cohen S, Spencer JA, Schajnovitz A, Ramasamy SK, Kusumbe AP, Ledergor G, Jung Y, Milo I, Poulos MG, Kalinkovich A, Ludin A, Golan K, Khatib E, Kumari A, Kollet O, Shakhar G, Butler JM, Rafii S, Adams RH, Scadden DT, Lin CP, Lapidot T

Corrigendum: Distinct bone marrow blood vessels differentially regulate haematopoiesis.
Nature. 2016;538(7624):274 - PMID: 27437586 - DOI: 10.1038/nature19088

Itkin T, Gur-Cohen S, Spencer JA, Schajnovitz A, Ramasamy SK, Kusumbe AP, Ledergor G, Jung Y, Milo I, Poulos MG, Kalinkovich A, Ludin A, Kollet O, Shakhar G, Butler JM, Rafii S, Adams RH, Scadden DT, Lin CP, Lapidot T

Distinct bone marrow blood vessels differentially regulate haematopoiesis.
Nature. 2016;532(7599):323-8 - PMID: 27074509 - PMCID: PMC6450701 - DOI: 10.1038/nature17624

Adams GB, Alley IR, Chung UI, Chabner KT, Jeanson NT, Lo Celso C, Marsters ES, Chen M, Weinstein LS, Lin CP, Kronenberg HM, Scadden DT

Haematopoietic stem cells depend on Galpha(s)-mediated signalling to engraft bone marrow.
Nature. 2009;459(7243):103-7 - PMID: 19322176 - PMCID: PMC2761017 - DOI: 10.1038/nature07859

Fujisaki J, Wu J, Carlson AL, Silberstein L, Putheti P, Larocca R, Gao W, Saito TI, Lo Celso C, Tsuyuzaki H, Sato T, Côté D, Sykes M, Strom TB, Scadden DT, Lin CP

In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche.
Nature. 2011;474(7350):216-9 - PMID: 21654805 - PMCID: PMC3725645 - DOI: 10.1038/nature10160

Dutta P, Courties G, Wei Y, Leuschner F, Gorbatov R, Robbins CS, Iwamoto Y, Thompson B, Carlson AL, Heidt T, Majmudar MD, Lasitschka F, Etzrodt M, Waterman P, Waring MT, Chicoine AT, van der Laan AM, Niessen HW, Piek JJ, Rubin BB, Butany J, Stone JR, Katus HA, Murphy SA, Morrow DA, Sabatine MS, Vinegoni C, Moskowitz MA, Pittet MJ, Libby P, Lin CP, Swirski FK, Weissleder R, Nahrendorf M

Myocardial infarction accelerates atherosclerosis.
Nature. 2012;487(7407):325-9 - PMID: 22763456 - PMCID: PMC3401326 - DOI: 10.1038/nature11260

Ksander BR, Kolovou PE, Wilson BJ, Saab KR, Guo Q, Ma J, McGuire SP, Gregory MS, Vincent WJ, Perez VL, Cruz-Guilloty F, Kao WW, Call MK, Tucker BA, Zhan Q, Murphy GF, Lathrop KL, Alt C, Mortensen LJ, Lin CP, Zieske JD, Frank MH, Frank NY

ABCB5 is a limbal stem cell gene required for corneal development and repair.
Nature. 2014;511(7509):353-7 - PMID: 25030174 - PMCID: PMC4246512 - DOI: 10.1038/nature13426

Spencer JA, Ferraro F, Roussakis E, Klein A, Wu J, Runnels JM, Zaher W, Mortensen LJ, Alt C, Turcotte R, Yusuf R, Côté D, Vinogradov SA, Scadden DT, Lin CP

Direct measurement of local oxygen concentration in the bone marrow of live animals.
Nature. 2014;508(7495):269-73 - PMID: 24590072 - PMCID: PMC3984353 - DOI: 10.1038/nature13034

Yu VWC, Yusuf RZ, Oki T, Wu J, Saez B, Wang X, Cook C, Baryawno N, Ziller MJ, Lee E, Gu H, Meissner A, Lin CP, Kharchenko PV, Scadden DT

Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells.
Cell. 2017;168(5):944-945 - PMID: 28235203 - PMCID: PMC5510238 - DOI: 10.1016/j.cell.2017.02.010

Hulsmans M, Clauss S, Xiao L, Aguirre AD, King KR, Hanley A, Hucker WJ, Wülfers EM, Seemann G, Courties G, Iwamoto Y, Sun Y, Savol AJ, Sager HB, Lavine KJ, Fishbein GA, Capen DE, Da Silva N, Miquerol L, Wakimoto H, Seidman CE, Seidman JG, Sadreyev RI, Naxerova K, Mitchell RN, Brown D, Libby P, Weissleder R, Swirski FK, Kohl P, Vinegoni C, Milan DJ, Ellinor PT, Nahrendorf M

Macrophages Facilitate Electrical Conduction in the Heart.
Cell. 2017;169(3):510-522.e20 - PMID: 28431249 - PMCID: PMC5474950 - DOI: 10.1016/j.cell.2017.03.050

Aceto N, Bardia A, Miyamoto DT, Donaldson MC, Wittner BS, Spencer JA, Yu M, Pely A, Engstrom A, Zhu H, Brannigan BW, Kapur R, Stott SL, Shioda T, Ramaswamy S, Ting DT, Lin CP, Toner M, Haber DA, Maheswaran S

Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis.
Cell. 2014;158(5):1110-1122 - PMID: 25171411 - PMCID: PMC4149753 - DOI: 10.1016/j.cell.2014.07.013

Kong L, Tang J, Little JP, Yu Y, Lämmermann T, Lin CP, Germain RN, Cui M

Continuous volumetric imaging via an optical phase-locked ultrasound lens.
Nat Methods. 2015;12(8):759-62 - PMID: 26167641 - PMCID: PMC4551496 - DOI: 10.1038/nmeth.3476

Ito K, Turcotte R, Cui J, Zimmerman SE, Pinho S, Mizoguchi T, Arai F, Runnels JM, Alt C, Teruya-Feldstein J, Mar JC, Singh R, Suda T, Lin CP, Frenette PS, Ito K

Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance.
Science. 2016;354(6316):1156-1160 - PMID: 27738012 - PMCID: PMC5164878 - DOI: 10.1126/science.aaf5530

Huang D, Swanson EA, Lin CP, Schuman JS, Stinson WG, Chang W, Hee MR, Flotte T, Gregory K, Puliafito CA

Optical coherence tomography.
Science. 1991;254(5035):1178-81 - PMID: 1957169 - PMCID: PMC4638169 - DOI: 10.1126/science.1957169

van der Sijde JN, Karanasos A, Villiger M, Bouma BE, Regar E

First-in-man assessment of plaque rupture by polarization-sensitive optical frequency domain imaging in vivo.
Eur Heart J. 2016;37(24):1932 - PMID: 27174288 - PMCID: PMC4917748 - DOI: 10.1093/eurheartj/ehw179

Bourantas CV, Jaffer FA, Gijsen FJ, van Soest G, Madden SP, Courtney BK, Fard AM, Tenekecioglu E, Zeng Y, van der Steen AFW, Emelianov S, Muller J, Stone PH, Marcu L, Tearney GJ, Serruys PW

Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology.
Eur Heart J. 2017;38(6):400-412 - PMID: 27118197 - PMCID: PMC5837589 - DOI: 10.1093/eurheartj/ehw097

Hara T, Ughi GJ, McCarthy JR, Erdem SS, Mauskapf A, Lyon SC, Fard AM, Edelman ER, Tearney GJ, Jaffer FA

Intravascular fibrin molecular imaging improves the detection of unhealed stents assessed by optical coherence tomography in vivo.
Eur Heart J. 2015;38(6):447-455 - PMID: 26685129 - PMCID: PMC5837565 - DOI: 10.1093/eurheartj/ehv677

Koskinas KC, Ughi GJ, Windecker S, Tearney GJ, Räber L

Intracoronary imaging of coronary atherosclerosis: validation for diagnosis, prognosis and treatment.
Eur Heart J. 2015;37(6):524-35a-c - PMID: 26655874 - DOI: 10.1093/eurheartj/ehv642

Leuschner F, Courties G, Dutta P, Mortensen LJ, Gorbatov R, Sena B, Novobrantseva TI, Borodovsky A, Fitzgerald K, Koteliansky V, Iwamoto Y, Bohlender M, Meyer S, Lasitschka F, Meder B, Katus HA, Lin C, Libby P, Swirski FK, Anderson DG, Weissleder R, Nahrendorf M

Silencing of CCR2 in myocarditis.
Eur Heart J. 2014;36(23):1478-88 - PMID: 24950695 - PMCID: PMC4465633 - DOI: 10.1093/eurheartj/ehu225

Yu B, Kang SY, Akthakul A, Ramadurai N, Pilkenton M, Patel A, Nashat A, Anderson DG, Sakamoto FH, Gilchrest BA, Anderson RR, Langer R

An elastic second skin.
Nat Mater. 2016;15(8):911-8 - PMID: 27159017 - DOI: 10.1038/nmat4635

Spring BQ, Bryan Sears R, Zheng LZ, Mai Z, Watanabe R, Sherwood ME, Schoenfeld DA, Pogue BW, Pereira SP, Villa E, Hasan T

A photoactivable multi-inhibitor nanoliposome for tumour control and simultaneous inhibition of treatment escape pathways.
Nat Nanotechnol. 2016;11(4):378-87 - PMID: 26780659 - PMCID: PMC4821671 - DOI: 10.1038/nnano.2015.311

Guo J, Liu X, Jiang N, Yetisen AK, Yuk H, Yang C, Khademhosseini A, Zhao X, Yun SH

Highly Stretchable, Strain Sensing Hydrogel Optical Fibers.
Adv Mater. 2016;28(46):10244-10249 - PMID: 27714887 - PMCID: PMC5148684 - DOI: 10.1002/adma.201603160

Yetisen AK, Jiang N, Fallahi A, Montelongo Y, Ruiz-Esparza GU, Tamayol A, Zhang YS, Mahmood I, Yang SA, Kim KS, Butt H, Khademhosseini A, Yun SH

Glucose-Sensitive Hydrogel Optical Fibers Functionalized with Phenylboronic Acid.
Adv Mater. 2017;29(15):ePub - PMID: 28195436 - PMCID: PMC5921932 - DOI: 10.1002/adma.201606380

Yetisen AK, Coskun AF, England G, Cho S, Butt H, Hurwitz J, Kolle M, Khademhosseini A, Hart AJ, Folch A, Yun SH

Art on the Nanoscale and Beyond.
Adv Mater. 2015;28(9):1724-42 - PMID: 26671704 - DOI: 10.1002/adma.201502382

Baugh LM, Liu Z, Quinn KP, Osseiran S, Evans CL, Huggins GS, Hinds PW, Black LD, Georgakoudi I

Non-destructive two-photon excited fluorescence imaging identifies early nodules in calcific aortic-valve disease.
Nat Biomed Eng. 2017;1(11):914-924 - PMID: 29456878 - PMCID: PMC5811202 - DOI: 10.1038/s41551-017-0152-3

Yun SH, Kwok SJJ

Light in diagnosis, therapy and surgery.
Nat Biomed Eng. 2017;1:ePub - PMID: 28649464 - PMCID: PMC5476943 - DOI: 10.1038/s41551-016-0008

Alsayed Y, Ngo H, Runnels J, Leleu X, Singha UK, Pitsillides CM, Spencer JA, Kimlinger T, Ghobrial JM, Jia X, Lu G, Timm M, Kumar A, Côté D, Veilleux I, Hedin KE, Roodman GD, Witzig TE, Kung AL, Hideshima T, Anderson KC, Lin CP, Ghobrial IM

Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma.
Blood. 2007;109(7):2708-17 - PMID: 17119115 - PMCID: PMC1852222 - DOI: 10.1182/blood-2006-07-035857

Azab AK, Runnels JM, Pitsillides C, Moreau AS, Azab F, Leleu X, Jia X, Wright R, Ospina B, Carlson AL, Alt C, Burwick N, Roccaro AM, Ngo HT, Farag M, Melhem MR, Sacco A, Munshi NC, Hideshima T, Rollins BJ, Anderson KC, Kung AL, Lin CP, Ghobrial IM

CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy.
Blood. 2009;113(18):4341-51 - PMID: 19139079 - PMCID: PMC2676090 - DOI: 10.1182/blood-2008-10-186668

Sarkar D, Spencer JA, Phillips JA, Zhao W, Schafer S, Spelke DP, Mortensen LJ, Ruiz JP, Vemula PK, Sridharan R, Kumar S, Karnik R, Lin CP, Karp JM

Engineered cell homing.
Blood. 2011;118(25):e184-91 - PMID: 22034631 - PMCID: PMC3242725 - DOI: 10.1182/blood-2010-10-311464

Saez B, Ferraro F, Yusuf RZ, Cook CM, Yu VW, Pardo-Saganta A, Sykes SM, Palchaudhuri R, Schajnovitz A, Lotinun S, Lymperi S, Mendez-Ferrer S, Toro RD, Day R, Vasic R, Acharya SS, Baron R, Lin CP, Yamaguchi Y, Wagers AJ, Scadden DT

Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning.
Blood. 2014;124(19):2937-47 - PMID: 25202142 - PMCID: PMC4224192 - DOI: 10.1182/blood-2014-08-593426

Silberstein L, Goncalves KA, Kharchenko PV, Turcotte R, Kfoury Y, Mercier F, Baryawno N, Severe N, Bachand J, Spencer JA, Papazian A, Lee D, Chitteti BR, Srour EF, Hoggatt J, Tate T, Lo Celso C, Ono N, Nutt S, Heino J, Sipilä K, Shioda T, Osawa M, Lin CP, Hu GF, Scadden DT

Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators.
Cell Stem Cell. 2016;19(4):530-543 - PMID: 27524439 - PMCID: PMC5402355 - DOI: 10.1016/j.stem.2016.07.004

Park D, Spencer JA, Koh BI, Kobayashi T, Fujisaki J, Clemens TL, Lin CP, Kronenberg HM, Scadden DT

Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration.
Cell Stem Cell. 2012;10(3):259-72 - PMID: 22385654 - PMCID: PMC3652251 - DOI: 10.1016/j.stem.2012.02.003

Xing L, Higuma T, Wang Z, Aguirre AD, Mizuno K, Takano M, Dauerman HL, Park SJ, Jang Y, Kim CJ, Kim SJ, Choi SY, Itoh T, Uemura S, Lowe H, Walters DL, Barlis P, Lee S, Lerman A, Toma C, Tan JWC, Yamamoto E, Bryniarski K, Dai J, Zanchin T, Zhang S, Yu B, Lee H, Fujimoto J, Fuster V, Jang IK

Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography: A 4-Year Follow-Up Study.
J Am Coll Cardiol. 2017;69(20):2502-2513 - PMID: 28521888 - DOI: 10.1016/j.jacc.2017.03.556

Jia H, Abtahian F, Aguirre AD, Lee S, Chia S, Lowe H, Kato K, Yonetsu T, Vergallo R, Hu S, Tian J, Lee H, Park SJ, Jang YS, Raffel OC, Mizuno K, Uemura S, Itoh T, Kakuta T, Choi SY, Dauerman HL, Prasad A, Toma C, McNulty I, Zhang S, Yu B, Fuster V, Narula J, Virmani R, Jang IK

In vivo diagnosis of plaque erosion and calcified nodule in patients with acute coronary syndrome by intravascular optical coherence tomography.
J Am Coll Cardiol. 2013;62(19):1748-58 - PMID: 23810884 - PMCID: PMC3874870 - DOI: 10.1016/j.jacc.2013.05.071

Hu S, Yonetsu T, Jia H, Karanasos A, Aguirre AD, Tian J, Abtahian F, Vergallo R, Soeda T, Lee H, McNulty I, Kato K, Yu B, Mizuno K, Toutouzas K, Stefanadis C, Jang IK

Residual thrombus pattern in patients with ST-segment elevation myocardial infarction caused by plaque erosion versus plaque rupture after successful fibrinolysis: an optical coherence tomography study.
J Am Coll Cardiol. 2013;63(13):1336-1338 - PMID: 24361315 - DOI: 10.1016/j.jacc.2013.11.025

Evans CL

Endomicroscope sheds light on cervical tissue.
Sci Transl Med. 2017;9(372):ePub - PMID: 28077680 - DOI: 10.1126/scitranslmed.aal4989

Evans CL

New near-infrared dyes light up deep tissue imaging.
Sci Transl Med. 2017;9(378):ePub - PMID: 28228597 - DOI: 10.1126/scitranslmed.aam6065

Evans CL

Photoacoustic imaging sounds the alarm on liver fibrosis.
Sci Transl Med. 2016;8(366):366ec186 - PMID: 27881817 - DOI: 10.1126/scitranslmed.aal2794

Adams DC, Hariri LP, Miller AJ, Wang Y, Cho JL, Villiger M, Holz JA, Szabari MV, Hamilos DL, Scott Harris R, Griffith JW, Bouma BE, Luster AD, Medoff BD, Suter MJ

Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo.
Sci Transl Med. 2016;8(359):359ra131 - PMID: 27708064 - PMCID: PMC5389120 - DOI: 10.1126/scitranslmed.aag1424

Zhang Q, Dong T, Li P, Wu MX

Noninvasive low-level laser therapy for thrombocytopenia.
Sci Transl Med. 2016;8(349):349ra101 - PMID: 27464749 - PMCID: PMC7392149 - DOI: 10.1126/scitranslmed.aaf4964

Ferraro F, Lymperi S, Méndez-Ferrer S, Saez B, Spencer JA, Yeap BY, Masselli E, Graiani G, Prezioso L, Rizzini EL, Mangoni M, Rizzoli V, Sykes SM, Lin CP, Frenette PS, Quaini F, Scadden DT

Diabetes impairs hematopoietic stem cell mobilization by altering niche function.
Sci Transl Med. 2011;3(104):104ra101 - PMID: 21998408 - PMCID: PMC3754876 - DOI: 10.1126/scitranslmed.3002191

Nichols AJ, Roussakis E, Klein OJ, Evans CL

Click-assembled, oxygen-sensing nanoconjugates for depth-resolved, near-infrared imaging in a 3D cancer model.
Angew Chem Int Ed Engl. 2014;53(14):3671-4 - PMID: 24590700 - PMCID: PMC4026265 - DOI: 10.1002/anie.201311303

Roussakis E, Li Z, Nichols AJ, Evans CL

Oxygen-Sensing Methods in Biomedicine from the Macroscale to the Microscale.
Angew Chem Int Ed Engl. 2015;54(29):8340-62 - PMID: 26084034 - DOI: 10.1002/anie.201410646

Zheng X, Sallum UW, Verma S, Athar H, Evans CL, Hasan T

Exploiting a bacterial drug-resistance mechanism: a light-activated construct for the destruction of MRSA.
Angew Chem Int Ed Engl. 2009;48(12):2148-51 - PMID: 19206126 - DOI: 10.1002/anie.200804804

Roussakis E, Li Z, Nowell NH, Nichols AJ, Evans CL

Bright, "Clickable" Porphyrins for the Visualization of Oxygenation under Ambient Light.
Angew Chem Int Ed Engl. 2015;54(49):14728-31 - PMID: 26510549 - PMCID: PMC4715754 - DOI: 10.1002/anie.201506847

Yetisen AK, Qu H, Manbachi A, Butt H, Dokmeci MR, Hinestroza JP, Skorobogatiy M, Khademhosseini A, Yun SH

Nanotechnology in Textiles.
ACS Nano. 2016;10(3):3042-68 - PMID: 26918485 - DOI: 10.1021/acsnano.5b08176
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