
Investigator: Tianhong Dai, PhD
My research interests include biomedical optics, dermatological laser therapy, photo-thermal therapy, photodynamic therapy, low-level laser/light therapy, UVC therapy, bio-heat transfer, optical measurement, and numerical simulation. Currently, my research focus on light-based therapy for multi-drug-resistant bacterial infections.
Publications
Ozdemir GD, Dos Anjos C, Ozdemir MA, Leanse LG, Dai T
Lights out for Superbugs: Is antimicrobial blue light a potential approach for future infection Control?. Adv Drug Deliv Rev. 2025;224:115654 - PMID: 40651507 - PMCID: PMC12338029 - DOI: 10.1016/j.addr.2025.115654Hui J, Moon W, Dong PT, Dos Anjos C, Negri L, Yan H, Wang Y, Tam J, Dai T, Anderson RR, Goverman J, Gelfand JA, Yun SH
Low-Irradiance Antimicrobial Blue Light-Bathing Therapy for Wound Infection Control. Adv Sci (Weinh). 2025;12(20):e2412493 - PMID: 40229974 - PMCID: PMC12120825 - DOI: 10.1002/advs.202412493Wang Y, Li X, Chen H, Yang X, Guo L, Ju R, Dai T, Li G
Antimicrobial blue light inactivation of Pseudomonas aeruginosa: Unraveling the multifaceted impact of wavelength, growth stage, and medium composition. J Photochem Photobiol B. 2024;259:113023 - PMID: 39241393 - PMCID: PMC11390306 - DOI: 10.1016/j.jphotobiol.2024.113023Hickok NJ, Li B, Oral E, Zaat SAJ, Armbruster DA, Atkins GJ, Chen AF, Coraça-Huber DC, Dai T, Greenfield EM, Kasinath R, Libera M, Marques CNH, Moriarty TF, Scott Phillips K, Raghuraman K, Ren D, Rimondini L, Saeed K, Schaer TP, Schwarz EM, Spiegel C, Stoodley P, Truong VK, Tsang SJ, Wildemann B, Zelmer AR, Zinkernagel AS
The 2023 Orthopedic Research Society's international consensus meeting on musculoskeletal infection: Summary from the in vitro section. J Orthop Res. 2024;42(3):512-517 - PMID: 38146070 - DOI: 10.1002/jor.25774Dos Anjos C, Wang Y, Truong-Bolduc QC, Bolduc PK, Liu M, Hooper DC, Anderson RR, Dai T, Leanse LG
Blue Light Compromises Bacterial β-Lactamases Activity to Overcome β-Lactam Resistance. Lasers Surg Med. 2024;56(7):673-681 - PMID: 39039622 - PMCID: PMC11665815 - DOI: 10.1002/lsm.23819Marasini S, Leanse LG, Dai T
Erratum to "Can microorganisms develop resistance against light based anti-infective agents?" [Adv. Drug Delivery Rev. 175 (2021) 113822]. Adv Drug Deliv Rev. 2023;199:114971 - PMID: 37380574 - DOI: 10.1016/j.addr.2023.114971Leanse LG, Marasini S, Dos Anjos C, Dai T
Antimicrobial Resistance: Is There a 'Light' at the End of the Tunnel?. Antibiotics (Basel). 2023;12(9):ePub - PMID: 37760734 - PMCID: PMC10525303 - DOI: 10.3390/antibiotics12091437Leanse LG, Anjos CD, Kaler KR, Hui J, Boyd JM, Hooper DC, Anderson RR, Dai T
Blue Light Potentiates Antibiotics in Bacteria via Parallel Pathways of Hydroxyl Radical Production and Enhanced Antibiotic Uptake. Adv Sci (Weinh). 2023;10(36):e2303731 - PMID: 37946633 - PMCID: PMC10754126 - DOI: 10.1002/advs.202303731Dos Anjos C, Leanse LG, Ribeiro MS, Sellera FP, Dropa M, Arana-Chavez VE, Lincopan N, Baptista MS, Pogliani FC, Dai T, Sabino CP
New Insights into the Bacterial Targets of Antimicrobial Blue Light. Microbiol Spectr. 2023;11(2):e0283322 - PMID: 36809152 - PMCID: PMC10101057 - DOI: 10.1128/spectrum.02833-22Dai T, Prestidge CA
Light and drug delivery-based antimicrobial therapies in the fight against infectious diseases. Adv Drug Deliv Rev. 2023;197:114792 - PMID: 36948462 - DOI: 10.1016/j.addr.2023.114792Luo S, Yang X, Wu S, Li Y, Wu J, Liu M, Liu Z, Yu K, Wang X, Dai T, Huang X, Hu X
Understanding a defensive response of methicillin-resistant Staphylococcus aureus after exposure to multiple cycles of sub-lethal blue light. FEMS Microbiol Lett. 2022;369(1):ePub - PMID: 35675215 - DOI: 10.1093/femsle/fnac050Dos Anjos C, Leanse LG, Liu X, Miranda HV, Anderson RR, Dai T
Antimicrobial Blue Light for Prevention and Treatment of Highly Invasive Vibrio vulnificus Burn Infection in Mice. Front Microbiol. 2022;13:932466 - PMID: 35903474 - PMCID: PMC9315199 - DOI: 10.3389/fmicb.2022.932466Akasov R, Khaydukov EV, Yamada M, Zvyagin AV, Leelahavanichkul A, Leanse LG, Dai T, Prow T
Nanoparticle enhanced blue light therapy. Adv Drug Deliv Rev. 2022;184:114198 - PMID: 35301045 - DOI: 10.1016/j.addr.2022.114198Mushtaq S, Yasin T, Saleem M, Dai T, Yameen MA
Potentiation of Antimicrobial Photodynamic Therapy by Curcumin-loaded Graphene Quantum Dots. Photochem Photobiol. 2021;98(1):202-210 - PMID: 34382232 - DOI: 10.1111/php.13503Leanse LG, Dos Anjos C, Mushtaq S, Dai T
Antimicrobial blue light: A 'Magic Bullet' for the 21st century and beyond?. Adv Drug Deliv Rev. 2021;180:114057 - PMID: 34800566 - PMCID: PMC8728809 - DOI: 10.1016/j.addr.2021.114057Besegato JF, de Melo PBG, Tamae PE, Alves APAR, Rondón LF, Leanse LG, Dos Anjos C, Casarin HH, Chinelatti MA, Faria G, Dai T, Bagnato VS, Rastelli ANS
How can biophotonics help dentistry to avoid or minimize cross infection by SARS-CoV-2?. Photodiagnosis Photodyn Ther. 2021;37:102682 - PMID: 34910994 - PMCID: PMC8666148 - DOI: 10.1016/j.pdpdt.2021.102682