Investigator: Tianhong Dai, PhD

My research interests include biomedical optics, dermatological laser therapy, photo-thermal therapy, photodynamic therapy, low-level laser/light therapy, UVC therapy, bio-heat transfer, optical measurement, and numerical simulation. Currently, my research focus on light-based therapy for multi-drug-resistant bacterial infections.

Publications

  • Ozdemir GD, Dos Anjos C, Ozdemir MA, Leanse LG, Dai T

    Lights out for Superbugs: Is antimicrobial blue light a potential approach for future infection Control?. Adv Drug Deliv Rev. 2025;224:115654 - PMID: 40651507 - PMCID: PMC12338029 - DOI: 10.1016/j.addr.2025.115654

  • Hui J, Moon W, Dong PT, Dos Anjos C, Negri L, Yan H, Wang Y, Tam J, Dai T, Anderson RR, Goverman J, Gelfand JA, Yun SH

    Low-Irradiance Antimicrobial Blue Light-Bathing Therapy for Wound Infection Control. Adv Sci (Weinh). 2025;12(20):e2412493 - PMID: 40229974 - PMCID: PMC12120825 - DOI: 10.1002/advs.202412493

  • Wang Y, Li X, Chen H, Yang X, Guo L, Ju R, Dai T, Li G

    Antimicrobial blue light inactivation of Pseudomonas aeruginosa: Unraveling the multifaceted impact of wavelength, growth stage, and medium composition. J Photochem Photobiol B. 2024;259:113023 - PMID: 39241393 - PMCID: PMC11390306 - DOI: 10.1016/j.jphotobiol.2024.113023

  • Hickok NJ, Li B, Oral E, Zaat SAJ, Armbruster DA, Atkins GJ, Chen AF, Coraça-Huber DC, Dai T, Greenfield EM, Kasinath R, Libera M, Marques CNH, Moriarty TF, Scott Phillips K, Raghuraman K, Ren D, Rimondini L, Saeed K, Schaer TP, Schwarz EM, Spiegel C, Stoodley P, Truong VK, Tsang SJ, Wildemann B, Zelmer AR, Zinkernagel AS

    The 2023 Orthopedic Research Society's international consensus meeting on musculoskeletal infection: Summary from the in vitro section. J Orthop Res. 2024;42(3):512-517 - PMID: 38146070 - DOI: 10.1002/jor.25774

  • Dos Anjos C, Wang Y, Truong-Bolduc QC, Bolduc PK, Liu M, Hooper DC, Anderson RR, Dai T, Leanse LG

    Blue Light Compromises Bacterial β-Lactamases Activity to Overcome β-Lactam Resistance. Lasers Surg Med. 2024;56(7):673-681 - PMID: 39039622 - PMCID: PMC11665815 - DOI: 10.1002/lsm.23819

  • Marasini S, Leanse LG, Dai T

    Erratum to "Can microorganisms develop resistance against light based anti-infective agents?" [Adv. Drug Delivery Rev. 175 (2021) 113822]. Adv Drug Deliv Rev. 2023;199:114971 - PMID: 37380574 - DOI: 10.1016/j.addr.2023.114971

  • Leanse LG, Marasini S, Dos Anjos C, Dai T

    Antimicrobial Resistance: Is There a 'Light' at the End of the Tunnel?. Antibiotics (Basel). 2023;12(9):ePub - PMID: 37760734 - PMCID: PMC10525303 - DOI: 10.3390/antibiotics12091437

  • Leanse LG, Anjos CD, Kaler KR, Hui J, Boyd JM, Hooper DC, Anderson RR, Dai T

    Blue Light Potentiates Antibiotics in Bacteria via Parallel Pathways of Hydroxyl Radical Production and Enhanced Antibiotic Uptake. Adv Sci (Weinh). 2023;10(36):e2303731 - PMID: 37946633 - PMCID: PMC10754126 - DOI: 10.1002/advs.202303731

  • Dos Anjos C, Leanse LG, Ribeiro MS, Sellera FP, Dropa M, Arana-Chavez VE, Lincopan N, Baptista MS, Pogliani FC, Dai T, Sabino CP

    New Insights into the Bacterial Targets of Antimicrobial Blue Light. Microbiol Spectr. 2023;11(2):e0283322 - PMID: 36809152 - PMCID: PMC10101057 - DOI: 10.1128/spectrum.02833-22

  • Dai T, Prestidge CA

    Light and drug delivery-based antimicrobial therapies in the fight against infectious diseases. Adv Drug Deliv Rev. 2023;197:114792 - PMID: 36948462 - DOI: 10.1016/j.addr.2023.114792

  • Wong NCK, Meshkinfamfard S, Turbé V, Whitaker M, Moshe M, Bardanzellu A, Dai T, Pignatelli E, Barclay W, Darzi A, Elliott P, Ward H, Tanaka RJ, Cooke GS, McKendry RA, Atchison CJ, Bharath AA

    Machine learning to support visual auditing of home-based lateral flow immunoassay self-test results for SARS-CoV-2 antibodies. Commun Med (Lond). 2022;2:78 - PMID: 35814295 - PMCID: PMC9259560 - DOI: 10.1038/s43856-022-00146-z

  • Luo S, Yang X, Wu S, Li Y, Wu J, Liu M, Liu Z, Yu K, Wang X, Dai T, Huang X, Hu X

    Understanding a defensive response of methicillin-resistant Staphylococcus aureus after exposure to multiple cycles of sub-lethal blue light. FEMS Microbiol Lett. 2022;369(1):ePub - PMID: 35675215 - DOI: 10.1093/femsle/fnac050

  • Dos Anjos C, Leanse LG, Liu X, Miranda HV, Anderson RR, Dai T

    Antimicrobial Blue Light for Prevention and Treatment of Highly Invasive Vibrio vulnificus Burn Infection in Mice. Front Microbiol. 2022;13:932466 - PMID: 35903474 - PMCID: PMC9315199 - DOI: 10.3389/fmicb.2022.932466

  • Akasov R, Khaydukov EV, Yamada M, Zvyagin AV, Leelahavanichkul A, Leanse LG, Dai T, Prow T

    Nanoparticle enhanced blue light therapy. Adv Drug Deliv Rev. 2022;184:114198 - PMID: 35301045 - DOI: 10.1016/j.addr.2022.114198

  • Marasini S, Leanse LG, Dai T

    Can microorganisms develop resistance against light based anti-infective agents?. Adv Drug Deliv Rev. 2021;175:113822 - PMID: 34089778 - DOI: 10.1016/j.addr.2021.05.032

  • Lu M, Wang S, Wang T, Hu S, Bhayana B, Ishii M, Kong Y, Cai Y, Dai T, Cui W, Wu MX

    Bacteria-specific phototoxic reactions triggered by blue light and phytochemical carvacrol. Sci Transl Med. 2021;13(575):ePub - PMID: 33408183 - DOI: 10.1126/scitranslmed.aba3571

  • Lu M, Dai T, Murray CK, Wu MX

    Corrigendum: Bactericidal Property of Oregano Oil Against Multidrug-Resistant Clinical Isolates. Front Microbiol. 2021;12:713573 - PMID: 34322110 - PMCID: PMC8312647 - DOI: 10.3389/fmicb.2021.713573

  • Leanse LG, Zeng X, Dai T

    Potentiated antimicrobial blue light killing of methicillin resistant Staphylococcus aureus by pyocyanin. J Photochem Photobiol B. 2021;215:112109 - PMID: 33486397 - PMCID: PMC7856289 - DOI: 10.1016/j.jphotobiol.2020.112109

  • Leanse LG, Dos Anjos C, Wang Y, Murray CK, Hooper DC, Dai T

    Effective Treatment of Cutaneous Mold Infections by Antimicrobial Blue Light That Is Potentiated by Quinine. J Infect Dis. 2021;224(6):1069-1076 - PMID: 33528496 - PMCID: PMC8448430 - DOI: 10.1093/infdis/jiab058

  • Cotter EJ, Cotter LM, Franczek EB, Godfrey JJ, Hetzel SJ, Safdar N, Dai T, Arkin L, Grogan BF

    Efficacy of combinational therapy using blue light and benzoyl peroxide in reducing Cutibacterium acnes bioburden at the deltopectoral interval: a randomized controlled trial. J Shoulder Elbow Surg. 2021;30(12):2671-2681 - PMID: 34478863 - DOI: 10.1016/j.jse.2021.08.008

  • Mushtaq S, Yasin T, Saleem M, Dai T, Yameen MA

    Potentiation of Antimicrobial Photodynamic Therapy by Curcumin-loaded Graphene Quantum Dots. Photochem Photobiol. 2021;98(1):202-210 - PMID: 34382232 - DOI: 10.1111/php.13503

  • Leanse LG, Dos Anjos C, Mushtaq S, Dai T

    Antimicrobial blue light: A 'Magic Bullet' for the 21st century and beyond?. Adv Drug Deliv Rev. 2021;180:114057 - PMID: 34800566 - PMCID: PMC8728809 - DOI: 10.1016/j.addr.2021.114057

  • Besegato JF, de Melo PBG, Tamae PE, Alves APAR, Rondón LF, Leanse LG, Dos Anjos C, Casarin HH, Chinelatti MA, Faria G, Dai T, Bagnato VS, Rastelli ANS

    How can biophotonics help dentistry to avoid or minimize cross infection by SARS-CoV-2?. Photodiagnosis Photodyn Ther. 2021;37:102682 - PMID: 34910994 - PMCID: PMC8666148 - DOI: 10.1016/j.pdpdt.2021.102682

  • Liu T, Luo W, Ma L, Huang JJ, Stathaki T, Dai T

    Coupled Network for Robust Pedestrian Detection With Gated Multi-Layer Feature Extraction and Deformable Occlusion Handling. IEEE Trans Image Process. 2020;30:754-766 - PMID: 33237856 - DOI: 10.1109/TIP.2020.3038371