Investigator: Brett Bouma, PhD

Phone: 857-282-9088
Email: bouma@mgh.harvard.edu
Lab: Bouma, Brett

Brett E. Bouma, PhD, is a Professor of Dermatology and Health Sciences and Technology at Harvard Medical School and an Physicist in the Wellman Center for Photomedicine at the Massachusetts General Hospital. His doctoral dissertation research, in the physics department of the University of Illinois, Chicago, focused on understanding the interaction of ultrafast laser pulses with optical materials and plasmas.


Following the completion of his graduate work, he entered a post-doctoral fellowship in the EECS department at MIT where he continued his work with ultrafast lasers and began to explore applications in medicine and biology. Since starting a lab at MGH in 1998, he has focused his research on the development and clinical application of novel optical technologies for diagnosis and therapy. Professor Bouma is a Fellow of the Optical Society of America.

Publications

  • Schmidt G, McAuley R, Bouma BE, Uribe-Patarroyo N

    Asynchronous optical coherence elastography and directional phase gradient analysis. J Biomed Opt. 2025;30(12):124506 - PMID: 40979890 - PMCID: PMC12447186 - DOI: 10.1117/1.JBO.30.12.124506

  • Bak S, Park SM, Song Y, Kim J, Nam TW, Han DW, Kim CS, Cho SW, Bouma BE, Lee H

    High spectral energy density all-fiber nanosecond pulsed 1.7 μm light source for photoacoustic microscopy. Photoacoustics. 2025;44:100744 - PMID: 40606570 - PMCID: PMC12221601 - DOI: 10.1016/j.pacs.2025.100744

  • Araki M, Park SJ, Dauerman HL, Uemura S, Kim JS, Di Mario C, Johnson TW, Guagliumi G, Kastrati A, Joner M, Holm NR, Alfonso F, Wijns W, Adriaenssens T, Nef H, Rioufol G, Amabile N, Souteyrand G, Meneveau N, Gerbaud E, Opolski MP, Gonzalo N, Tearney GJ, Bouma B, Aguirre AD, Mintz GS, Stone GW, Bourantas CV, Räber L, Gili S, Mizuno K, Kimura S, Shinke T, Hong MK, Jang Y, Cho JM, Yan BP, Porto I, Niccoli G, Montone RA, Thondapu V, Papafaklis MI, Michalis LK, Reynolds H, Saw J, Libby P, Weisz G, Iannaccone M, Gori T, Toutouzas K, Yonetsu T, Minami Y, Takano M, Raffel OC, Kurihara O, Soeda T, Sugiyama T, Kim HO, Lee T, Higuma T, Nakajima A, Yamamoto E, Bryniarski KL, Di Vito L, Vergallo R, Fracassi F, Russo M, Seegers LM, McNulty I, Park S, Feldman M, Escaned J, Prati F, Arbustini E, Pinto FJ, Waksman R, Garcia-Garcia HM, Maehara A, Ali Z, Finn AV, Virmani R, Kini AS, Daemen J, Kume T, Hibi K, Tanaka A, Akasaka T, Kubo T, Yasuda S, Croce K, Granada JF, Lerman A, Prasad A, Regar E, Saito Y, Sankardas MA, Subban V, Weissman NJ, Chen Y, Yu B, Nicholls SJ, Barlis P, West NEJ, Arbab-Zadeh A, Ye JC, Dijkstra J, Lee H, Narula J, Crea F, Nakamura S, Kakuta T, Fujimoto J, Fuster V, Jang IK

    Author Correction: Optical coherence tomography in coronary atherosclerosis assessment and intervention. Nat Rev Cardiol. 2024;21(5):348 - PMID: 38110566 - PMCID: PMC11987009 - DOI: 10.1038/s41569-023-00982-z

  • Haft-Javaherian M, Villiger M, Otsuka K, Daemen J, Libby P, Golland P, Bouma BE

    Segmentation of anatomical layers and imaging artifacts in intravascular polarization sensitive optical coherence tomography using attending physician and boundary cardinality losses. Biomed Opt Express. 2024;15(3):1719-1738 - PMID: 38495711 - PMCID: PMC10942710 - DOI: 10.1364/BOE.514673

  • Bec J, Zhou X, Villiger M, Southard JA, Bouma B, Marcu L

    Dual modality intravascular catheter system combining pulse-sampling fluorescence lifetime imaging and polarization-sensitive optical coherence tomography. Biomed Opt Express. 2024;15(4):2114-2132 - PMID: 38633060 - PMCID: PMC11019710 - DOI: 10.1364/BOE.516515

  • Jones GL, Albadawi H, Hariri LP, Bouma BE, Oklu R, Villiger M

    Aging of deep venous thrombosis in-vivo using polarization sensitive optical coherence tomography. Biomed Opt Express. 2024;15(6):3627-3638 - PMID: 38867781 - PMCID: PMC11166430 - DOI: 10.1364/BOE.522238

  • Rao Chintada B, Keahey P, Uribe-Patarroyo N, Bouma BE, Villiger M

    Sample tilting for speckle suppression through angular compounding. Opt Lett. 2024;49(17):4979-4982 - PMID: 39208013 - PMCID: PMC11827440 - DOI: 10.1364/OL.533271

  • Chintada BR, Ruiz-Lopera S, Restrepo R, Bouma BE, Villiger M, Uribe-Patarroyo N

    Probabilistic volumetric speckle suppression in OCT using deep learning. Biomed Opt Express. 2024;15(8):4453-4469 - PMID: 39346991 - PMCID: PMC11427188 - DOI: 10.1364/BOE.523716

  • Mansutti G, Villiger M, Bouma BE, Uribe-Patarroyo N

    Full-field amplitude speckle decorrelation angiography. Biomed Opt Express. 2024;15(10):5756-5772 - PMID: 39421771 - PMCID: PMC11482163 - DOI: 10.1364/BOE.530993

  • Masoumi S, Lee J, Jones GL, Quémener M, Parent M, Bouma BE, Hariri LP, Côté DC, Villiger M

    Absolute depth-resolved optic axis measurement with catheter-based polarization sensitive optical coherence tomography. Biomed Opt Express. 2024;15(12):6957-6976 - PMID: 39679397 - PMCID: PMC11640563 - DOI: 10.1364/BOE.538560

  • Lee H, Seeger MR, Bouma BE

    Electronically Controlled Dual-Wavelength Switchable SRS Fiber Amplifier in the NIR-II Region for Multispectral Photoacoustic Microscopy. Laser Photon Rev. 2024;18(10):ePub - PMID: 39720420 - PMCID: PMC11666251 - DOI: 10.1002/lpor.202400144

  • Schmidt G, Bouma BE, Uribe-Patarroyo N

    Asynchronous, semi-reverberant elastography. Optica. 2024;11(9):1285-1294 - PMID: 40109673 - PMCID: PMC11922557 - DOI: 10.1364/optica.528507

  • Ruiz-Lopera S, Restrepo R, Cannon TM, Villiger M, Bouma BE, Uribe-Patarroyo N

    Computational refocusing in phase-unstable polarization-sensitive optical coherence tomography. Opt Lett. 2023;48(18):4765-4768 - PMID: 37707897 - PMCID: PMC10871002 - DOI: 10.1364/OL.499051

  • Leitgeb RA, Bouma B, Grieve K, Hendon C, Podoleanu A, Wojtkowski M, Yasuno Y

    30 Years of Optical Coherence Tomography: introduction to the feature issue. Biomed Opt Express. 2023;14(10):5484-5487 - PMID: 37854547 - PMCID: PMC10581797 - DOI: 10.1364/BOE.505569

  • Lee SY, Parot VJ, Bouma BE, Villiger M

    Efficient dispersion modeling in optical multimode fiber. Light Sci Appl. 2023;12(1):31 - PMID: 36720851 - PMCID: PMC9889807 - DOI: 10.1038/s41377-022-01061-7

  • Jones GL, Xiong Q, Liu X, Bouma BE, Villiger M

    Single-input polarization-sensitive optical coherence tomography through a catheter. Biomed Opt Express. 2023;14(9):4609-4626 - PMID: 37791262 - PMCID: PMC10545192 - DOI: 10.1364/BOE.497123

  • Cannon TM, Bouma BE, Uribe-Patarroyo N

    Mapping optical scattering properties to physical particle information in singly and multiply scattering samples. Biomed Opt Express. 2023;14(8):4326-4348 - PMID: 37799686 - PMCID: PMC10549752 - DOI: 10.1364/BOE.494518

  • Chintada BR, Ruiz-Lopera S, Restrepo R, Bouma BE, Villiger M, Uribe-Patarroyo N

    Probabilistic volumetric speckle suppression in OCT using deep learning. ArXiv. 2023;:ePub - PMID: 38106457 - PMCID: PMC10723542

  • Pahlevaninezhad M, Huang YW, Pahlevani M, Bouma B, Suter MJ, Capasso F, Pahlevaninezhad H

    Metasurface-based bijective illumination collection imaging provides high-resolution tomography in three dimensions. Nat Photonics. 2022;16(3):203-211 - PMID: 35937091 - PMCID: PMC9355264 - DOI: 10.1038/s41566-022-00956-6

  • Lee SY, Parot VJ, Bouma BE, Villiger M

    Confocal 3D reflectance imaging through multimode fiber without wavefront shaping. Optica. 2022;9(1):112-120 - PMID: 35419464 - PMCID: PMC9005109 - DOI: 10.1364/OPTICA.446178

  • Lee H, Seeger MR, Lippok N, Nadkarni SK, van Soest G, Bouma BE

    Nanosecond SRS fiber amplifier for label-free near-infrared photoacoustic microscopy of lipids. Photoacoustics. 2022;25:100331 - PMID: 35096525 - PMCID: PMC8783138 - DOI: 10.1016/j.pacs.2022.100331

  • DePaoli D, Côté DC, Bouma BE, Villiger M

    Endoscopic imaging of white matter fiber tracts using polarization-sensitive optical coherence tomography. Neuroimage. 2022;264:119755 - PMID: 36400379 - PMCID: PMC9802682 - DOI: 10.1016/j.neuroimage.2022.119755

  • Cannon TM, Uribe-Patarroyo N, Villiger M, Bouma BE

    Measuring collagen injury depth for burn severity determination using polarization sensitive optical coherence tomography. Sci Rep. 2022;12(1):10479 - PMID: 35729262 - PMCID: PMC9213509 - DOI: 10.1038/s41598-022-14326-3

  • Araki M, Park SJ, Dauerman HL, Uemura S, Kim JS, Di Mario C, Johnson TW, Guagliumi G, Kastrati A, Joner M, Holm NR, Alfonso F, Wijns W, Adriaenssens T, Nef H, Rioufol G, Amabile N, Souteyrand G, Meneveau N, Gerbaud E, Opolski MP, Gonzalo N, Tearney GJ, Bouma B, Aguirre AD, Mintz GS, Stone GW, Bourantas CV, Räber L, Gili S, Mizuno K, Kimura S, Shinke T, Hong MK, Jang Y, Cho JM, Yan BP, Porto I, Niccoli G, Montone RA, Thondapu V, Papafaklis MI, Michalis LK, Reynolds H, Saw J, Libby P, Weisz G, Iannaccone M, Gori T, Toutouzas K, Yonetsu T, Minami Y, Takano M, Raffel OC, Kurihara O, Soeda T, Sugiyama T, Kim HO, Lee T, Higuma T, Nakajima A, Yamamoto E, Bryniarski KL, Di Vito L, Vergallo R, Fracassi F, Russo M, Seegers LM, McNulty I, Park S, Feldman M, Escaned J, Prati F, Arbustini E, Pinto FJ, Waksman R, Garcia-Garcia HM, Maehara A, Ali Z, Finn AV, Virmani R, Kini AS, Daemen J, Kume T, Hibi K, Tanaka A, Akasaka T, Kubo T, Yasuda S, Croce K, Granada JF, Lerman A, Prasad A, Regar E, Saito Y, Sankardas MA, Subban V, Weissman NJ, Chen Y, Yu B, Nicholls SJ, Barlis P, West NEJ, Arbab-Zadeh A, Ye JC, Dijkstra J, Lee H, Narula J, Crea F, Nakamura S, Kakuta T, Fujimoto J, Fuster V, Jang IK

    Optical coherence tomography in coronary atherosclerosis assessment and intervention. Nat Rev Cardiol. 2022;19(10):684-703 - PMID: 35449407 - PMCID: PMC9982688 - DOI: 10.1038/s41569-022-00687-9

  • van Zandvoort LJC, Otsuka K, Villiger M, Neleman T, Dijkstra J, Zijlstra F, van Mieghem NM, Bouma BE, Daemen J

    Polarimetric Signatures of Coronary Thrombus in Patients With Acute Coronary Syndrome. Circ J. 2021;85(10):1806-1813 - PMID: 33828020 - PMCID: PMC10782573 - DOI: 10.1253/circj.CJ-20-0862

  • Van Zandvoort LJC, Otsuka K, Bouma BE, Daemen J

    Intracoronary polarimetry of a honeycomb-like structure. EuroIntervention. 2021;16(17):1422-1423 - PMID: 31403462 - PMCID: PMC7238317 - DOI: 10.4244/EIJ-D-19-00431

  • Ren J, Shishkov M, Villiger ML, Otsuka K, Nadkarni SK, Bouma BE

    Single-catheter dual-modality intravascular imaging combining IVUS and OFDI: a holistic structural visualisation of coronary arteries. EuroIntervention. 2021;17(11):e919-e922 - PMID: 34219665 - PMCID: PMC8649034 - DOI: 10.4244/EIJ-D-20-00990

  • Ren J, Bouma BE

    Whole Murine Brain Imaging Based on Optical Elastic Scattering. Adv Exp Med Biol. 2021;3233:109-125 - PMID: 34053025 - DOI: 10.1007/978-981-15-7627-0_6

  • Keahey P, Si P, Razavi M, Yu S, Lippok N, Villiger M, Padera TP, de la Zerda A, Bouma B

    Spectral- and Polarization-Dependent Scattering of Gold Nanobipyramids for Exogenous Contrast in Optical Coherence Tomography. Nano Lett. 2021;21(20):8595-8601 - PMID: 34644094 - PMCID: PMC8555503 - DOI: 10.1021/acs.nanolett.1c02291

  • Cannon TM, Bouma BE, Uribe-Patarroyo N

    Layer-based, depth-resolved computation of attenuation coefficients and backscattering fractions in tissue using optical coherence tomography. Biomed Opt Express. 2021;12(8):5037-5056 - PMID: 34513241 - PMCID: PMC8407832 - DOI: 10.1364/BOE.427833

  • Struyvenberg M, Kahn A, Fleischer D, Swager AF, Bouma B, Ganguly EK, Konda V, Lightdale CJ, Pleskow D, Sethi A, Smith M, Trindade AJ, Wallace MB, Wang K, Wolfsen HC, Tearney GJ, Curvers WL, Leggett CL, Bergman JJ

    Expert assessment on volumetric laser endomicroscopy full scans in Barrett's esophagus patients with or without high grade dysplasia or early cancer. Endoscopy. 2020;53(3):218-225 - PMID: 32515006 - DOI: 10.1055/a-1194-0397

  • Snyder PJ, Alber J, Alt C, Bain LJ, Bouma BE, Bouwman FH, DeBuc DC, Campbell MCW, Carrillo MC, Chew EY, Cordeiro MF, Dueñas MR, Fernández BM, Koronyo-Hamaoui M, La Morgia C, Carare RO, Sadda SR, van Wijngaarden P, Snyder HM

    Retinal imaging in Alzheimer's and neurodegenerative diseases. Alzheimers Dement. 2020;17(1):103-111 - PMID: 33090722 - PMCID: PMC8062064 - DOI: 10.1002/alz.12179

  • Deliyski DD, Shishkov M, Mehta DD, Ghasemzadeh H, Bouma B, Zañartu M, de Alarcon A, Hillman RE

    Laser-Calibrated System for Transnasal Fiberoptic Laryngeal High-Speed Videoendoscopy. J Voice. 2019;35(1):122-128 - PMID: 31383516 - PMCID: PMC6995434 - DOI: 10.1016/j.jvoice.2019.07.013