Investigator: Brett Bouma, PhD

Phone: 857-282-9088
Email: bouma@mgh.harvard.edu
Lab: Bouma, Brett

Brett E. Bouma, PhD, is a Professor of Dermatology and Health Sciences and Technology at Harvard Medical School and an Physicist in the Wellman Center for Photomedicine at the Massachusetts General Hospital. His doctoral dissertation research, in the physics department of the University of Illinois, Chicago, focused on understanding the interaction of ultrafast laser pulses with optical materials and plasmas.


Following the completion of his graduate work, he entered a post-doctoral fellowship in the EECS department at MIT where he continued his work with ultrafast lasers and began to explore applications in medicine and biology. Since starting a lab at MGH in 1998, he has focused his research on the development and clinical application of novel optical technologies for diagnosis and therapy. Professor Bouma is a Fellow of the Optical Society of America.

Publications

  • Chen C, Gu P, Villiger M, Uribe-Patarroyo N, Bouma B, Ren J

    FUSION: A fast and uniform processing framework for whole-brain optical scattering tomography images. bioRxiv. 2026;:ePub - PMID: 41542411 - PMCID: PMC12803274 - DOI: 10.64898/2026.01.06.698063

  • Ruiz-Lopera S, Veysset D, Bouma BE, Uribe-Patarroyo N

    Wavenumber-space wavefront sensorless adaptive-optics for optical coherence tomography. Biomed Opt Express. 2025;17(1):282-293 - PMID: 41532101 - PMCID: PMC12795413 - DOI: 10.1364/BOE.582534

  • Truong NTP, Shishkov M, Jahan D, Bouma BE, Suter MJ, Adams DC

    Development and characterization of a clinically viable metalens-enhanced optical endoscope. Opt Express. 2025;33(23):49200-49210 - PMID: 41414318 - DOI: 10.1364/OE.570460

  • Lee PY, Chueh CB, Shishkov M, Wang TA, Chen T, Bouma BE, Villiger M

    Polarization-Sensitive Module for Optical Coherence Tomography Instruments. ArXiv. 2025;:ePub - PMID: 41293538 - PMCID: PMC12642765

  • Schmidt G, McAuley R, Bouma BE, Uribe-Patarroyo N

    Asynchronous optical coherence elastography and directional phase gradient analysis. J Biomed Opt. 2025;30(12):124506 - PMID: 40979890 - PMCID: PMC12447186 - DOI: 10.1117/1.JBO.30.12.124506

  • Bak S, Park SM, Song Y, Kim J, Nam TW, Han DW, Kim CS, Cho SW, Bouma BE, Lee H

    High spectral energy density all-fiber nanosecond pulsed 1.7 μm light source for photoacoustic microscopy. Photoacoustics. 2025;44:100744 - PMID: 40606570 - PMCID: PMC12221601 - DOI: 10.1016/j.pacs.2025.100744

  • Araki M, Park SJ, Dauerman HL, Uemura S, Kim JS, Di Mario C, Johnson TW, Guagliumi G, Kastrati A, Joner M, Holm NR, Alfonso F, Wijns W, Adriaenssens T, Nef H, Rioufol G, Amabile N, Souteyrand G, Meneveau N, Gerbaud E, Opolski MP, Gonzalo N, Tearney GJ, Bouma B, Aguirre AD, Mintz GS, Stone GW, Bourantas CV, Räber L, Gili S, Mizuno K, Kimura S, Shinke T, Hong MK, Jang Y, Cho JM, Yan BP, Porto I, Niccoli G, Montone RA, Thondapu V, Papafaklis MI, Michalis LK, Reynolds H, Saw J, Libby P, Weisz G, Iannaccone M, Gori T, Toutouzas K, Yonetsu T, Minami Y, Takano M, Raffel OC, Kurihara O, Soeda T, Sugiyama T, Kim HO, Lee T, Higuma T, Nakajima A, Yamamoto E, Bryniarski KL, Di Vito L, Vergallo R, Fracassi F, Russo M, Seegers LM, McNulty I, Park S, Feldman M, Escaned J, Prati F, Arbustini E, Pinto FJ, Waksman R, Garcia-Garcia HM, Maehara A, Ali Z, Finn AV, Virmani R, Kini AS, Daemen J, Kume T, Hibi K, Tanaka A, Akasaka T, Kubo T, Yasuda S, Croce K, Granada JF, Lerman A, Prasad A, Regar E, Saito Y, Sankardas MA, Subban V, Weissman NJ, Chen Y, Yu B, Nicholls SJ, Barlis P, West NEJ, Arbab-Zadeh A, Ye JC, Dijkstra J, Lee H, Narula J, Crea F, Nakamura S, Kakuta T, Fujimoto J, Fuster V, Jang IK

    Author Correction: Optical coherence tomography in coronary atherosclerosis assessment and intervention. Nat Rev Cardiol. 2024;21(5):348 - PMID: 38110566 - PMCID: PMC11987009 - DOI: 10.1038/s41569-023-00982-z

  • Haft-Javaherian M, Villiger M, Otsuka K, Daemen J, Libby P, Golland P, Bouma BE

    Segmentation of anatomical layers and imaging artifacts in intravascular polarization sensitive optical coherence tomography using attending physician and boundary cardinality losses. Biomed Opt Express. 2024;15(3):1719-1738 - PMID: 38495711 - PMCID: PMC10942710 - DOI: 10.1364/BOE.514673

  • Bec J, Zhou X, Villiger M, Southard JA, Bouma B, Marcu L

    Dual modality intravascular catheter system combining pulse-sampling fluorescence lifetime imaging and polarization-sensitive optical coherence tomography. Biomed Opt Express. 2024;15(4):2114-2132 - PMID: 38633060 - PMCID: PMC11019710 - DOI: 10.1364/BOE.516515

  • Jones GL, Albadawi H, Hariri LP, Bouma BE, Oklu R, Villiger M

    Aging of deep venous thrombosis in-vivo using polarization sensitive optical coherence tomography. Biomed Opt Express. 2024;15(6):3627-3638 - PMID: 38867781 - PMCID: PMC11166430 - DOI: 10.1364/BOE.522238

  • Rao Chintada B, Keahey P, Uribe-Patarroyo N, Bouma BE, Villiger M

    Sample tilting for speckle suppression through angular compounding. Opt Lett. 2024;49(17):4979-4982 - PMID: 39208013 - PMCID: PMC11827440 - DOI: 10.1364/OL.533271

  • Chintada BR, Ruiz-Lopera S, Restrepo R, Bouma BE, Villiger M, Uribe-Patarroyo N

    Probabilistic volumetric speckle suppression in OCT using deep learning. Biomed Opt Express. 2024;15(8):4453-4469 - PMID: 39346991 - PMCID: PMC11427188 - DOI: 10.1364/BOE.523716

  • Mansutti G, Villiger M, Bouma BE, Uribe-Patarroyo N

    Full-field amplitude speckle decorrelation angiography. Biomed Opt Express. 2024;15(10):5756-5772 - PMID: 39421771 - PMCID: PMC11482163 - DOI: 10.1364/BOE.530993

  • Masoumi S, Lee J, Jones GL, Quémener M, Parent M, Bouma BE, Hariri LP, Côté DC, Villiger M

    Absolute depth-resolved optic axis measurement with catheter-based polarization sensitive optical coherence tomography. Biomed Opt Express. 2024;15(12):6957-6976 - PMID: 39679397 - PMCID: PMC11640563 - DOI: 10.1364/BOE.538560

  • Lee H, Seeger MR, Bouma BE

    Electronically Controlled Dual-Wavelength Switchable SRS Fiber Amplifier in the NIR-II Region for Multispectral Photoacoustic Microscopy. Laser Photon Rev. 2024;18(10):ePub - PMID: 39720420 - PMCID: PMC11666251 - DOI: 10.1002/lpor.202400144

  • Schmidt G, Bouma BE, Uribe-Patarroyo N

    Asynchronous, semi-reverberant elastography. Optica. 2024;11(9):1285-1294 - PMID: 40109673 - PMCID: PMC11922557 - DOI: 10.1364/optica.528507

  • Ruiz-Lopera S, Restrepo R, Cannon TM, Villiger M, Bouma BE, Uribe-Patarroyo N

    Computational refocusing in phase-unstable polarization-sensitive optical coherence tomography. Opt Lett. 2023;48(18):4765-4768 - PMID: 37707897 - PMCID: PMC10871002 - DOI: 10.1364/OL.499051

  • Leitgeb RA, Bouma B, Grieve K, Hendon C, Podoleanu A, Wojtkowski M, Yasuno Y

    30 Years of Optical Coherence Tomography: introduction to the feature issue. Biomed Opt Express. 2023;14(10):5484-5487 - PMID: 37854547 - PMCID: PMC10581797 - DOI: 10.1364/BOE.505569

  • Lee SY, Parot VJ, Bouma BE, Villiger M

    Efficient dispersion modeling in optical multimode fiber. Light Sci Appl. 2023;12(1):31 - PMID: 36720851 - PMCID: PMC9889807 - DOI: 10.1038/s41377-022-01061-7

  • Jones GL, Xiong Q, Liu X, Bouma BE, Villiger M

    Single-input polarization-sensitive optical coherence tomography through a catheter. Biomed Opt Express. 2023;14(9):4609-4626 - PMID: 37791262 - PMCID: PMC10545192 - DOI: 10.1364/BOE.497123

  • Cannon TM, Bouma BE, Uribe-Patarroyo N

    Mapping optical scattering properties to physical particle information in singly and multiply scattering samples. Biomed Opt Express. 2023;14(8):4326-4348 - PMID: 37799686 - PMCID: PMC10549752 - DOI: 10.1364/BOE.494518

  • Chintada BR, Ruiz-Lopera S, Restrepo R, Bouma BE, Villiger M, Uribe-Patarroyo N

    Probabilistic volumetric speckle suppression in OCT using deep learning. ArXiv. 2023;:ePub - PMID: 38106457 - PMCID: PMC10723542

  • Pahlevaninezhad M, Huang YW, Pahlevani M, Bouma B, Suter MJ, Capasso F, Pahlevaninezhad H

    Metasurface-based bijective illumination collection imaging provides high-resolution tomography in three dimensions. Nat Photonics. 2022;16(3):203-211 - PMID: 35937091 - PMCID: PMC9355264 - DOI: 10.1038/s41566-022-00956-6

  • Lee SY, Parot VJ, Bouma BE, Villiger M

    Confocal 3D reflectance imaging through multimode fiber without wavefront shaping. Optica. 2022;9(1):112-120 - PMID: 35419464 - PMCID: PMC9005109 - DOI: 10.1364/OPTICA.446178

  • Lee H, Seeger MR, Lippok N, Nadkarni SK, van Soest G, Bouma BE

    Nanosecond SRS fiber amplifier for label-free near-infrared photoacoustic microscopy of lipids. Photoacoustics. 2022;25:100331 - PMID: 35096525 - PMCID: PMC8783138 - DOI: 10.1016/j.pacs.2022.100331

  • DePaoli D, Côté DC, Bouma BE, Villiger M

    Endoscopic imaging of white matter fiber tracts using polarization-sensitive optical coherence tomography. Neuroimage. 2022;264:119755 - PMID: 36400379 - PMCID: PMC9802682 - DOI: 10.1016/j.neuroimage.2022.119755

  • Cannon TM, Uribe-Patarroyo N, Villiger M, Bouma BE

    Measuring collagen injury depth for burn severity determination using polarization sensitive optical coherence tomography. Sci Rep. 2022;12(1):10479 - PMID: 35729262 - PMCID: PMC9213509 - DOI: 10.1038/s41598-022-14326-3

  • Araki M, Park SJ, Dauerman HL, Uemura S, Kim JS, Di Mario C, Johnson TW, Guagliumi G, Kastrati A, Joner M, Holm NR, Alfonso F, Wijns W, Adriaenssens T, Nef H, Rioufol G, Amabile N, Souteyrand G, Meneveau N, Gerbaud E, Opolski MP, Gonzalo N, Tearney GJ, Bouma B, Aguirre AD, Mintz GS, Stone GW, Bourantas CV, Räber L, Gili S, Mizuno K, Kimura S, Shinke T, Hong MK, Jang Y, Cho JM, Yan BP, Porto I, Niccoli G, Montone RA, Thondapu V, Papafaklis MI, Michalis LK, Reynolds H, Saw J, Libby P, Weisz G, Iannaccone M, Gori T, Toutouzas K, Yonetsu T, Minami Y, Takano M, Raffel OC, Kurihara O, Soeda T, Sugiyama T, Kim HO, Lee T, Higuma T, Nakajima A, Yamamoto E, Bryniarski KL, Di Vito L, Vergallo R, Fracassi F, Russo M, Seegers LM, McNulty I, Park S, Feldman M, Escaned J, Prati F, Arbustini E, Pinto FJ, Waksman R, Garcia-Garcia HM, Maehara A, Ali Z, Finn AV, Virmani R, Kini AS, Daemen J, Kume T, Hibi K, Tanaka A, Akasaka T, Kubo T, Yasuda S, Croce K, Granada JF, Lerman A, Prasad A, Regar E, Saito Y, Sankardas MA, Subban V, Weissman NJ, Chen Y, Yu B, Nicholls SJ, Barlis P, West NEJ, Arbab-Zadeh A, Ye JC, Dijkstra J, Lee H, Narula J, Crea F, Nakamura S, Kakuta T, Fujimoto J, Fuster V, Jang IK

    Optical coherence tomography in coronary atherosclerosis assessment and intervention. Nat Rev Cardiol. 2022;19(10):684-703 - PMID: 35449407 - PMCID: PMC9982688 - DOI: 10.1038/s41569-022-00687-9

  • van Zandvoort LJC, Otsuka K, Villiger M, Neleman T, Dijkstra J, Zijlstra F, van Mieghem NM, Bouma BE, Daemen J

    Polarimetric Signatures of Coronary Thrombus in Patients With Acute Coronary Syndrome. Circ J. 2021;85(10):1806-1813 - PMID: 33828020 - PMCID: PMC10782573 - DOI: 10.1253/circj.CJ-20-0862

  • Van Zandvoort LJC, Otsuka K, Bouma BE, Daemen J

    Intracoronary polarimetry of a honeycomb-like structure. EuroIntervention. 2021;16(17):1422-1423 - PMID: 31403462 - PMCID: PMC7238317 - DOI: 10.4244/EIJ-D-19-00431

  • Ren J, Shishkov M, Villiger ML, Otsuka K, Nadkarni SK, Bouma BE

    Single-catheter dual-modality intravascular imaging combining IVUS and OFDI: a holistic structural visualisation of coronary arteries. EuroIntervention. 2021;17(11):e919-e922 - PMID: 34219665 - PMCID: PMC8649034 - DOI: 10.4244/EIJ-D-20-00990

  • Ren J, Bouma BE

    Whole Murine Brain Imaging Based on Optical Elastic Scattering. Adv Exp Med Biol. 2021;3233:109-125 - PMID: 34053025 - DOI: 10.1007/978-981-15-7627-0_6

  • Keahey P, Si P, Razavi M, Yu S, Lippok N, Villiger M, Padera TP, de la Zerda A, Bouma B

    Spectral- and Polarization-Dependent Scattering of Gold Nanobipyramids for Exogenous Contrast in Optical Coherence Tomography. Nano Lett. 2021;21(20):8595-8601 - PMID: 34644094 - PMCID: PMC8555503 - DOI: 10.1021/acs.nanolett.1c02291

  • Cannon TM, Bouma BE, Uribe-Patarroyo N

    Layer-based, depth-resolved computation of attenuation coefficients and backscattering fractions in tissue using optical coherence tomography. Biomed Opt Express. 2021;12(8):5037-5056 - PMID: 34513241 - PMCID: PMC8407832 - DOI: 10.1364/BOE.427833

  • Ruiz-Lopera S, Restrepo R, Cuartas-Velez C, Bouma BE, Uribe-Patarroyo N

    Computational adaptive optics in phase-unstable optical coherence tomography. Opt Lett. 2020;45(21):5982-5985 - PMID: 33137049 - PMCID: PMC8384075 - DOI: 10.1364/OL.401283

  • Park EA, Tsikata E, Lee JJ, Shieh E, Braaf B, Vakoc BJ, Bouma BE, de Boer JF, Chen TC

    Artifact Rates for 2D Retinal Nerve Fiber Layer Thickness Versus 3D Neuroretinal Rim Thickness Using Spectral-Domain Optical Coherence Tomography. Transl Vis Sci Technol. 2020;9(10):10 - PMID: 32974082 - PMCID: PMC7488619 - DOI: 10.1167/tvst.9.10.10

  • Otsuka K, Villiger M, van Zandvoort LJC, Neleman T, Karanasos A, Dijkstra J, van Soest G, Regar E, Nadkarni SK, Daemen J, Bouma BE

    Polarimetric Signatures of Vascular Tissue Response to Drug-Eluting Stent Implantation in Patients. JACC Cardiovasc Imaging. 2020;13(12):2695-2696 - PMID: 32828773 - PMCID: PMC7736522 - DOI: 10.1016/j.jcmg.2020.07.009

  • Lee SY, Parot VJ, Bouma BE, Villiger M

    Reciprocity-induced symmetry in the round-trip transmission through complex systems. APL Photonics. 2020;5(10):ePub - PMID: 33088915 - PMCID: PMC7575207 - DOI: 10.1063/5.0021285

  • Lee H, Kim GH, Villiger M, Jang H, Bouma BE, Kim CS

    Linear-in-wavenumber actively-mode-locked wavelength-swept laser. Opt Lett. 2020;45(19):5327-5330 - PMID: 33001885 - PMCID: PMC7574329 - DOI: 10.1364/OL.397715

  • Lee SY, Hui PC, Bouma B, Villiger M

    Single-shot depth profiling by spatio-temporal encoding with a multimode fiber. Opt Express. 2020;28(2):1124-1138 - PMID: 32121828 - PMCID: PMC7053500 - DOI: 10.1364/OE.383145

  • Keahey PA, Bouma BE, Villiger M

    Automated noise estimation in polarization-sensitive optical coherence tomography. Opt Lett. 2020;45(10):2748-2751 - PMID: 32412457 - PMCID: PMC7506521 - DOI: 10.1364/OL.390334

  • Struyvenberg M, Kahn A, Fleischer D, Swager AF, Bouma B, Ganguly EK, Konda V, Lightdale CJ, Pleskow D, Sethi A, Smith M, Trindade AJ, Wallace MB, Wang K, Wolfsen HC, Tearney GJ, Curvers WL, Leggett CL, Bergman JJ

    Expert assessment on volumetric laser endomicroscopy full scans in Barrett's esophagus patients with or without high grade dysplasia or early cancer. Endoscopy. 2020;53(3):218-225 - PMID: 32515006 - DOI: 10.1055/a-1194-0397

  • Snyder PJ, Alber J, Alt C, Bain LJ, Bouma BE, Bouwman FH, DeBuc DC, Campbell MCW, Carrillo MC, Chew EY, Cordeiro MF, Dueñas MR, Fernández BM, Koronyo-Hamaoui M, La Morgia C, Carare RO, Sadda SR, van Wijngaarden P, Snyder HM

    Retinal imaging in Alzheimer's and neurodegenerative diseases. Alzheimers Dement. 2020;17(1):103-111 - PMID: 33090722 - PMCID: PMC8062064 - DOI: 10.1002/alz.12179

  • Xiong Q, Wang N, Liu X, Chen S, Braganza CS, Bouma BE, Liu L, Villiger M

    Constrained polarization evolution simplifies depth-resolved retardation measurements with polarization-sensitive optical coherence tomography. Biomed Opt Express. 2019;10(10):5207-5222 - PMID: 31646042 - PMCID: PMC6788597 - DOI: 10.1364/BOE.10.005207

  • López-Marín A, Springeling G, Beurskens R, van Beusekom H, van der Steen AFW, Koch AD, Bouma BE, Huber R, van Soest G, Wang T

    Motorized capsule for shadow-free OCT imaging and synchronous beam control. Opt Lett. 2019;44(15):3641-3644 - PMID: 31368932 - DOI: 10.1364/OL.44.003641

  • Lo WCY, Uribe-Patarroyo N, Hoebel K, Beaudette K, Villiger M, Nishioka NS, Vakoc BJ, Bouma BE

    Balloon catheter-based radiofrequency ablation monitoring in porcine esophagus using optical coherence tomography. Biomed Opt Express. 2019;10(4):2067-2089 - PMID: 31086717 - PMCID: PMC6484999 - DOI: 10.1364/BOE.10.002067

  • Liu Y, Jassim F, Braaf B, Khoueir Z, Poon LY, Ben-David GS, Papadogeorgou G, Tsikata E, Simavli H, Que C, Lee R, Shieh E, Vakoc BJ, Bouma BE, de Boer JF, Chen TC

    Diagnostic Capability of 3D Peripapillary Retinal Volume for Glaucoma Using Optical Coherence Tomography Customized Software. J Glaucoma. 2019;28(8):708-717 - PMID: 31180936 - PMCID: PMC6727946 - DOI: 10.1097/IJG.0000000000001291

  • Khoueir Z, Jassim F, Braaf B, Poon LY, Tsikata E, Chodosh J, Dohlman CH, Vakoc BJ, Bouma BE, de Boer JF, Chen TC

    Three-Dimensional Optical Coherence Tomography Imaging For Glaucoma Associated With Boston Keratoprosthesis Type I and II. J Glaucoma. 2019;28(8):718-726 - PMID: 31169563 - PMCID: PMC6727947 - DOI: 10.1097/IJG.0000000000001280

  • Hariri LP, Adams DC, Applegate MB, Miller AJ, Roop BW, Villiger M, Bouma BE, Suter MJ

    Distinguishing Tumor from Associated Fibrosis to Increase Diagnostic Biopsy Yield with Polarization-Sensitive Optical Coherence Tomography. Clin Cancer Res. 2019;25(17):5242-5249 - PMID: 31175092 - PMCID: PMC6726561 - DOI: 10.1158/1078-0432.CCR-19-0566

  • Otsuka K, Villiger M, Karanasos A, van Zandvoort LJC, Doradla P, Ren J, Lippok N, Daemen J, Diletti R, van Geuns RJ, Zijlstra F, van Soest G, Dijkstra J, Nadkarni SK, Regar E, Bouma BE

    Intravascular Polarimetry in Patients With Coronary Artery Disease. JACC Cardiovasc Imaging. 2019;13(3):790-801 - PMID: 31422135 - PMCID: PMC7241775 - DOI: 10.1016/j.jcmg.2019.06.015

  • Doradla P, Otsuka K, Nadkarni A, Villiger M, Karanasos A, Zandvoort LJCV, Dijkstra J, Zijlstra F, Soest GV, Daemen J, Regar E, Bouma BE, Nadkarni SK

    Biomechanical Stress Profiling of Coronary Atherosclerosis: Identifying a Multifactorial Metric to Evaluate Plaque Rupture Risk. JACC Cardiovasc Imaging. 2019;13(3):804-816 - PMID: 31005542 - PMCID: PMC9919872 - DOI: 10.1016/j.jcmg.2019.01.033

  • Deliyski DD, Shishkov M, Mehta DD, Ghasemzadeh H, Bouma B, Zañartu M, de Alarcon A, Hillman RE

    Laser-Calibrated System for Transnasal Fiberoptic Laryngeal High-Speed Videoendoscopy. J Voice. 2019;35(1):122-128 - PMID: 31383516 - PMCID: PMC6995434 - DOI: 10.1016/j.jvoice.2019.07.013

  • Nam AS, Ren J, Bouma BE, Vakoc BJ

    Demonstration of Triband Multi-Focal Imaging with Optical Coherence Tomography. Appl Sci (Basel). 2018;8(12):ePub - PMID: 31308961 - PMCID: PMC6628925 - DOI: 10.3390/app8122395

  • Lippok N, Braaf B, Villiger M, Oh WY, Vakoc BJ, Bouma BE

    Quantitative depolarization measurements for fiber-based polarization-sensitive optical frequency domain imaging of the retinal pigment epithelium. J Biophotonics. 2018;12(1):e201800156 - PMID: 30009506 - PMCID: PMC6526942 - DOI: 10.1002/jbio.201800156

  • Golberg A, Villiger M, Felix Broelsch G, Quinn KP, Albadawi H, Khan S, Watkins MT, Georgakoudi I, Austen WG, Bei M, Bouma BE, Mihm MC, Yarmush ML

    Skin regeneration with all accessory organs following ablation with irreversible electroporation. J Tissue Eng Regen Med. 2017;12(1):98-113 - PMID: 27976527 - PMCID: PMC5555830 - DOI: 10.1002/term.2374

  • Villiger M, Otsuka K, Karanasos A, Doradla P, Ren J, Lippok N, Shishkov M, Daemen J, Diletti R, van Geuns RJ, Zijlstra F, van Soest G, Libby P, Regar E, Nadkarni SK, Bouma BE

    Coronary Plaque Microstructure and Composition Modify Optical Polarization: A New Endogenous Contrast Mechanism for Optical Frequency Domain Imaging. JACC Cardiovasc Imaging. 2017;11(11):1666-1676 - PMID: 29248662 - PMCID: PMC5994172 - DOI: 10.1016/j.jcmg.2017.09.023

  • Ren J, Choi H, Chung K, Bouma BE

    Label-free volumetric optical imaging of intact murine brains. Sci Rep. 2017;7:46306 - PMID: 28401897 - PMCID: PMC5388920 - DOI: 10.1038/srep46306

  • Liu X, Beaudette K, Wang X, Liu L, Bouma BE, Villiger M

    Tissue-like phantoms for quantitative birefringence imaging. Biomed Opt Express. 2017;8(10):4454-4465 - PMID: 29082077 - PMCID: PMC5654792 - DOI: 10.1364/BOE.8.004454

  • Lippok N, Villiger M, Albanese A, Meijer EFJ, Chung K, Padera TP, Bhatia SN, Bouma BE

    Depolarization signatures map gold nanorods within biological tissue. Nat Photonics. 2017;11:583-588 - PMID: 29201136 - PMCID: PMC5703429 - DOI: 10.1038/nphoton.2017.128

  • Kravez E, Villiger M, Bouma B, Yarmush M, Yakhini Z, Golberg A

    Prediction of Scar Size in Rats Six Months after Burns Based on Early Post-injury Polarization-Sensitive Optical Frequency Domain Imaging. Front Physiol. 2017;8:967 - PMID: 29249978 - PMCID: PMC5717021 - DOI: 10.3389/fphys.2017.00967

  • Khoueir Z, Jassim F, Poon LY, Tsikata E, Ben-David GS, Liu Y, Shieh E, Lee R, Guo R, Papadogeorgou G, Braaf B, Simavli H, Que C, Vakoc BJ, Bouma BE, de Boer JF, Chen TC

    Diagnostic Capability of Peripapillary Three-dimensional Retinal Nerve Fiber Layer Volume for Glaucoma Using Optical Coherence Tomography Volume Scans. Am J Ophthalmol. 2017;182:180-193 - PMID: 28807732 - PMCID: PMC5610646 - DOI: 10.1016/j.ajo.2017.08.001

  • Kassani SH, Villiger M, Uribe-Patarroyo N, Jun C, Khazaeinezhad R, Lippok N, Bouma BE

    Extended bandwidth wavelength swept laser source for high resolution optical frequency domain imaging. Opt Express. 2017;25(7):8255-8266 - PMID: 28380940 - PMCID: PMC5810910 - DOI: 10.1364/OE.25.008255

  • Izatt JA, Boppart S, Bouma B, de Boer J, Drexler W, Li X, Yasuno Y

    Introduction to the feature issue on the 25 year anniversary of optical coherence tomography. Biomed Opt Express. 2017;8(7):3289-3291 - PMID: 28717567 - PMCID: PMC5508828 - DOI: 10.1364/BOE.8.003289

  • Bouma BE, Villiger M, Otsuka K, Oh WY

    Intravascular optical coherence tomography [Invited]. Biomed Opt Express. 2017;8(5):2660-2686 - PMID: 28663897 - PMCID: PMC5480504 - DOI: 10.1364/BOE.8.002660

  • Villiger M, Lorenser D, McLaughlin RA, Quirk BC, Kirk RW, Bouma BE, Sampson DD

    Deep tissue volume imaging of birefringence through fibre-optic needle probes for the delineation of breast tumour. Sci Rep. 2016;6:28771 - PMID: 27364229 - PMCID: PMC4929466 - DOI: 10.1038/srep28771

  • van der Sijde JN, Karanasos A, Villiger M, Bouma BE, Regar E

    First-in-man assessment of plaque rupture by polarization-sensitive optical frequency domain imaging in vivo. Eur Heart J. 2016;37(24):1932 - PMID: 27174288 - PMCID: PMC4917748 - DOI: 10.1093/eurheartj/ehw179

  • Uribe-Patarroyo N, Bouma BE

    Velocity gradients in spatially resolved laser Doppler flowmetry and dynamic light scattering with confocal and coherence gating. Phys Rev E. 2016;94(2-1):022604 - PMID: 27627357 - PMCID: PMC5059111 - DOI: 10.1103/PhysRevE.94.022604

  • Rico-Jimenez JJ, Campos-Delgado DU, Villiger M, Otsuka K, Bouma BE, Jo JA

    Automatic classification of atherosclerotic plaques imaged with intravascular OCT. Biomed Opt Express. 2016;7(10):4069-4085 - PMID: 27867716 - PMCID: PMC5102521 - DOI: 10.1364/BOE.7.004069

  • Lo WCY, Villiger M, Golberg A, Broelsch GF, Khan S, Lian CG, Austen WG, Yarmush M, Bouma BE

    Longitudinal, 3D Imaging of Collagen Remodeling in Murine Hypertrophic Scars In Vivo Using Polarization-Sensitive Optical Frequency Domain Imaging. J Invest Dermatol. 2016;136(1):84-92 - PMID: 26763427 - PMCID: PMC4809366 - DOI: 10.1038/JID.2015.399

  • Kim TS, Park HS, Jang SJ, Song JW, Cho HS, Kim S, Bouma BE, Kim JW, Oh WY

    Single cardiac cycle three-dimensional intracoronary optical coherence tomography. Biomed Opt Express. 2016;7(12):4847-4858 - PMID: 28018710 - PMCID: PMC5175536 - DOI: 10.1364/BOE.7.004847

  • Jang SJ, Park HS, Song JW, Kim TS, Cho HS, Kim S, Bouma BE, Kim JW, Oh WY

    ECG-Triggered, Single Cardiac Cycle, High-Speed, 3D, Intracoronary OCT. JACC Cardiovasc Imaging. 2016;9(5):623-5 - PMID: 27151525 - PMCID: PMC5523103 - DOI: 10.1016/j.jcmg.2015.11.021

  • Golberg A, Villiger M, Khan S, Quinn KP, Lo WCY, Bouma BE, Mihm MC, Austen WG, Yarmush ML

    Preventing Scars after Injury with Partial Irreversible Electroporation. J Invest Dermatol. 2016;136(11):2297-2304 - PMID: 27393126 - PMCID: PMC5516938 - DOI: 10.1016/j.jid.2016.06.620

  • Blatter C, Meijer EF, Nam AS, Jones D, Bouma BE, Padera TP, Vakoc BJ

    In vivo label-free measurement of lymph flow velocity and volumetric flow rates using Doppler optical coherence tomography. Sci Rep. 2016;6:29035 - PMID: 27377852 - PMCID: PMC4932526 - DOI: 10.1038/srep29035

  • Adams DC, Hariri LP, Miller AJ, Wang Y, Cho JL, Villiger M, Holz JA, Szabari MV, Hamilos DL, Scott Harris R, Griffith JW, Bouma BE, Luster AD, Medoff BD, Suter MJ

    Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo. Sci Transl Med. 2016;8(359):359ra131 - PMID: 27708064 - PMCID: PMC5389120 - DOI: 10.1126/scitranslmed.aag1424

  • Lo WC, Uribe-Patarroyo N, Nam AS, Villiger M, Vakoc BJ, Bouma BE

    Laser thermal therapy monitoring using complex differential variance in optical coherence tomography. J Biophotonics. 2016;10(1):84-91 - PMID: 27623742 - PMCID: PMC5243231 - DOI: 10.1002/jbio.201600072

  • Gerbaud E, Weisz G, Tanaka A, Kashiwagi M, Shimizu T, Wang L, Souza C, Bouma BE, Suter MJ, Shishkov M, Ughi GJ, Halpern EF, Rosenberg M, Waxman S, Moses JW, Mintz GS, Maehara A, Tearney GJ

    Multi-laboratory inter-institute reproducibility study of IVOCT and IVUS assessments using published consensus document definitions. Eur Heart J Cardiovasc Imaging. 2015;17(7):756-64 - PMID: 26377904 - PMCID: PMC4907381 - DOI: 10.1093/ehjci/jev229