Investigator: Aaron Aguirre, MD, PhD

Phone: 617-726-8828
Email: aaguirre1@mgh.harvard.edu
Lab: Aguirre, Aaron

Aaron Aguirre, M.D., PhD is a physician-scientist and an attending cardiologist at the Massachusetts General Hospital and an Assistant Professor of Medicine at Harvard Medical School. Aaron received his M.D. from Harvard Medical School and his Ph.D. in electrical and biomedical engineering from the Massachusetts Institute of Technology, where he worked with Prof. James Fujimoto on high resolution optical coherence tomography methods. He then did residency and fellowship training at the Brigham and Women’s Hospital before completing a postdoctoral research fellowship in cardiovascular imaging at the MGH Center for Systems Biology with Prof. Ralph Weissleder.

Dr. Aguirre’s laboratory at MGH is now part of the Wellman Center for Photomedicine and the Center for Systems Biology and is closely affiliated with the MGH Cardiovascular Research Center.

As a critical care cardiologist in the MGH Heart Center Intensive Care Unit, his clinical practice involves care of medical and surgical patients with all forms of advanced heart disease. He has particular interest in the area of acute decompensated heart failure and the use of mechanical circulatory support devices.

Selected Publications (from total 48)

  • Li J, Aguirre AD, Moura V, Jin J, Liu C, Zhong L, Sun C, Clifford G, Westover MB, Hong S

    An Electrocardiogram Foundation Model Built on over 10 Million Recordings. NEJM AI. 2025;2(7):ePub - PMID: 40771651 - PMCID: PMC12327759 - DOI: 10.1056/aioa2401033

  • Palanques-Tost E, Pallarès-López R, Padrós-Valls R, Song S, Reinertsen E, Churchill TW, Stockwell P, Pomerantsev E, Garasic J, Sundt TM, Shah P, Houstis NE, Aguirre AD

    Cardiac Output Estimation in the Intensive Care Unit. JACC Adv. 2025;4(5):101663 - PMID: 40286350 - PMCID: PMC12101535 - DOI: 10.1016/j.jacadv.2025.101663

  • Foy BH, Carlson JCT, Aguirre AD, Higgins JM

    Platelet-white cell ratio is more strongly associated with mortality than other common risk ratios derived from complete blood counts. Nat Commun. 2025;16(1):1113 - PMID: 39875373 - PMCID: PMC11775293 - DOI: 10.1038/s41467-025-56251-9

  • Ayers BC, Padrós-Valls R, Brownlee S, Steinhorn BS, Shann K, Osho A, Sundt TM, Aguirre AD

    Prebypass Critical Closing Pressure Predicts Acute Kidney Injury After Cardiopulmonary Bypass. J Cardiothorac Vasc Anesth. 2024;39(2):437-446 - PMID: 39645444 - DOI: 10.1053/j.jvca.2024.11.010

  • Chandrasekhar A, Padrós-Valls R, Pallarès-López R, Palanques-Tost E, Houstis N, Sundt TM, Lee HS, Sodini CG, Aguirre AD

    Tissue perfusion pressure enables continuous hemodynamic evaluation and risk prediction in the intensive care unit. Nat Med. 2023;29(8):1998-2006 - PMID: 37550417 - DOI: 10.1038/s41591-023-02474-6

  • Foy BH, Sundt TM, Carlson JCT, Aguirre AD, Higgins JM

    Human acute inflammatory recovery is defined by co-regulatory dynamics of white blood cell and platelet populations. Nat Commun. 2022;13(1):4705 - PMID: 35995789 - PMCID: PMC9395541 - DOI: 10.1038/s41467-022-32222-2

  • Aguirre AD, Arbab-Zadeh A, Soeda T, Fuster V, Jang IK

    Optical Coherence Tomography of Plaque Vulnerability and Rupture: JACC Focus Seminar Part 1/3. J Am Coll Cardiol. 2021;78(12):1257-1265 - PMID: 34531027 - PMCID: PMC9851427 - DOI: 10.1016/j.jacc.2021.06.050

  • Hulsmans M, Clauss S, Xiao L, Aguirre AD, King KR, Hanley A, Hucker WJ, Wülfers EM, Seemann G, Courties G, Iwamoto Y, Sun Y, Savol AJ, Sager HB, Lavine KJ, Fishbein GA, Capen DE, Da Silva N, Miquerol L, Wakimoto H, Seidman CE, Seidman JG, Sadreyev RI, Naxerova K, Mitchell RN, Brown D, Libby P, Weissleder R, Swirski FK, Kohl P, Vinegoni C, Milan DJ, Ellinor PT, Nahrendorf M

    Macrophages Facilitate Electrical Conduction in the Heart. Cell. 2017;169(3):510-522.e20 - PMID: 28431249 - PMCID: PMC5474950 - DOI: 10.1016/j.cell.2017.03.050

  • Vinegoni C, Aguirre AD, Lee S, Weissleder R

    Imaging the beating heart in the mouse using intravital microscopy techniques. Nat Protoc. 2015;10(11):1802-19 - PMID: 26492138 - PMCID: PMC5380003 - DOI: 10.1038/nprot.2015.119

  • Aguirre AD, Vinegoni C, Sebas M, Weissleder R

    Intravital imaging of cardiac function at the single-cell level. Proc Natl Acad Sci U S A. 2014;111(31):11257-62 - PMID: 25053815 - PMCID: PMC4128110 - DOI: 10.1073/pnas.1401316111