Li Y, Wu MX. Visualization and elimination of polymicrobial biofilms by a combination of ALA-carvacrol-blue light. J Photochem Photobiol B. 2022 Sep;234:112525. doi: 10.1016/j.jphotobiol.2022.112525. Epub 2022 Jul 11. PMID: 35841737.
Lu M, Wong KI, Li X, Wang F, Wei L, Wang S, Wu MX. Oregano Oil and Harmless Blue Light to Synergistically Inactivate Multidrug-Resistant Pseudomonas aeruginosa. Front Microbiol. 2022 Mar 10;13:810746. doi: 10.3389/fmicb.2022.810746. PMID: 35359746; PMCID: PMC8961286.
Wang S, Wong KI, Li Y, Ishii M, Li X, Wei L, Lu M, Wu MX. Blue light potentiates safety and bactericidal activity of p-Toluquinone. J Photochem Photobiol B. 2022 May;230:112427. doi: 10.1016/j.jphotobiol.2022.112427. Epub 2022 Mar 18. PMID: 35338920.
Yan M, Wu MX. Low-level light pre-conditioning promotes C2C12 myoblast differentiation under hypoxic conditions. J Biophotonics. 2022 Apr;15(4):e202100246. doi: 10.1002/jbio.202100246. Epub 2021 Dec 29. PMID: 34751510.
Chen F, Chen GX, Zhou J, Xue Y, Wu MX. Childhood Bacille Calmette-Guerin Vaccination and Its Association With Less Severe COVID-19 Pneumonia. Am J Prev Med. 2021 Apr 12:S0749-3797(21)00198-7. doi: 10.1016/j.amepre.2021.02.025. Epub ahead of print. PMID: 33985834; PMCID: PMC8041236.
Li Y, Wu MX. Reversal of Polymicrobial Biofilm Tolerance to Ciprofloxacin by Blue Light plus Carvacrol. Microorganisms. 2021 Oct 1;9(10):2074. doi: 10.3390/microorganisms9102074. PMID: 34683395; PMCID: PMC8539106.
Lin ZT, Gu J, Wang H, Wu A, Sun J, Chen S, Li Y, Kong Y, Wu MX, Wu T. Thermosensitive and Conductive Hybrid Polymer for Real-Time Monitoring of Spheroid Growth and Drug Responses. ACS Sens. 2021 May 20. doi: 10.1021/acssensors.0c02266. Epub ahead of print. PMID: 34014658.
Lu M, Dai T, Murray CK, Wu MX. Corrigendum: Bactericidal Property of Oregano Oil Against Multidrug-Resistant Clinical Isolates. Front Microbiol. 2021 Jul 12;12:713573. doi: 10.3389/fmicb.2021.713573. Erratum for: Front Microbiol. 2018 Oct 05;9:2329. PMID: 34322110; PMCID: PMC8312647.
Lu M, Li Y, Wu MX. Bacteria-specific pro-photosensitizer kills multidrug-resistant Staphylococcus aureus and Pseudomonas aeruginosa. Commun Biol. 2021 Mar 25;4(1):408. doi: 10.1038/s42003-021-01956-y. PMID: 33767385; PMCID: PMC7994569.
Lu M, Wang S, Wang T, Hu S, Bhayana B, Ishii M, Kong Y, Cai Y, Dai T, Cui W, Wu MX. Bacteria-specific phototoxic reactions triggered by blue light and phytochemical carvacrol. Sci Transl Med. 2021 Jan 6;13(575):eaba3571. doi: 10.1126/scitranslmed.aba3571. PMID: 33408183.
Wang Y, Kong Y, Wu MX. Innovative Systems to Deliver Allergen Powder for Epicutaneous Immunotherapy. Front Immunol. 2021 Mar 26;12:647954. doi: 10.3389/fimmu.2021.647954. PMID: 33841430; PMCID: PMC8033039.
Yan M, Wu MX. Low-level light pre-conditioning promotes C2C12 myoblast differentiation under hypoxic conditions. J Biophotonics. 2021 Nov 9:e202100246. doi: 10.1002/jbio.202100246. Epub ahead of print. PMID: 34751510.
Lu M, Wang S, Wang T, Hu SS, Bhayana B, Ishii M, Kong YF, Cai YC, Dai TH, Cui WG, Wu MX. Bacteria-specific Phototoxic Reactions Triggered by Blue Light and Phytochemical Carvacrol. Science Translational Medicine. 2021. 13(575):eaba3571.
Kong YF, Santos-Carballal D, Martin D, Sergeeva NN, Wang WL, Liu GS, Johnson B, Bhayana B, Lin ZT, Wang YS, Guével LX, de Leeuw NH, Zhou DJ, Wu MX. A NIR-II-emitting gold nanocluster-based drug delivery system for smartphone-triggered photodynamic theranostics with rapid body clearance. Materials Today. 2021. Volume 51: 96-107.
Lu M, Dai T, Hu S, Zhang Q, Bhayana B, Wang L, Wu MX. Antimicrobial blue light for decontamination of platelets during storage. J Biophotonics. 2020 Jan;13(1):e201960021.
Yang Y, Kumar MNK, Wu MX. Delivery of Allergen Powder for Safe and Effective Epicutaneous Immunotherapy. Journal of Allergy and Clinical Immunology. 2020. Feb. 21: 367(6480). doi: 10.1126/science.aau0810.
• Editorial summary of the paper “Toward a universal flu vaccine” by Drs. Herold and Sander in the same Science issue.
• Featured in this week in Science “Pitching cGAMP as vaccine strategy” by Editor Dr. Seth Thomas Scanlon on the front page
• Nominated for the Martin Prize in 2021
• Receiving the Celebration of Science Recognition Award from Mass General Brigham
• Featured in Precision-Medicine
• Cited by paper Chase in Harvard Medical School News
• Highlighted in MGH Research Institute Snapshot of Science “New Insights into influenza vaccines”
• Interviewed by a Science Journalist for La Repubblica
Wang WL, Kong YF, Jiang J, Wu D, Zheng HZ, Gao M, Xu SJ, Pan YX, Li W, Ma RL, Wu MX, Li RB. Engineering Gold Nanoclusters for Sensitive Imaging of Gastrointestinal Tumors in the Second Near-infrared Window. Angew Chem Int Ed Engl. 2020. 59(50):22431-22435.
Wang J, Li PY, Yang Y, Fu YH, Sun ZP, Jiang SB, Lu L, Wu MX. Pulmonary Surfactant-Biomimetic Nanoparticles Potentiate Heterosubtypic Influenza Immunity. Science. 2020.145 (2):597-609.
Liu GS, Yang F, Xu J, Kong Y, Zheng H, Chen L, Chen Y, Wu MX, Yang BR, Luo Y, Chen Z. Ultrasonically Patterning Silver Nanowire-Acrylate Composite for Highly Sensitive and Transparent Strain Sensors Based on Parallel Cracks. ACS Appl Mater Interfaces. 2020. 12(42):47729-47738.
Yang JK, Wang L, Wu MX. Low-level light treatment promotes engraftment of human umbilical cord blood-derived hematopoietic stem and progenitor cells. Scientific Reports. 2020. 10(1):19671.
Chen HJ, Hang T, Yang C, Liu D, Su C, Xiao S, Liu C, Lin DA, Zhang T, Jin Q, Tao J, Wu MX, Wang J, Xie X. Functionalized Spiky Particles for Intracellular Biomolecular Delivery. ACS Cent Sci. 2019 Jun 26;5(6):960-969. PMCID: PMC6598163
Jiang H, Bian Q, Zeng W, Ren P, Sun H, Lin Z, Tang Z, Zhou X, Wang Q, Wang Y, Wang Y, Wu MX, Li X, Yu X, Huang Y. Oral delivery of Bacillus subtilis spores expressing grass carp reovirus VP4 protein produces protection against grass carp reovirus infection. Fish Shellfish Immunol. 2019 Jan;84:768-780.
Liu GS, Kong Y, Wang Y, Luo Y, Fan X, Xie X, Yang BR, Wu MX. Microneedles for transdermal diagnostics: Recent advances and new horizons. Biomaterials. 2019 Dec 26;232:119740.
Wang L, Xie R, Fan Z, Yang J, Liang W, Wu Q, Wu MX, Wang Z, Lu Y. The contribution of oxidative stress to platelet senescence during storage. Transfusion. 2019 Jul;59(7):2389-2402.
Yu Y, Kiran Kumar MN, Wu MX. Delivery of allergen powder for safe and effective epicutaneous immunotherapy. J Allergy Clin Immunol. 2019 Nov 27. pii: S0091-6749(19)31605-7. [Epub ahead of print]
Zhang Q, Lu M, Wu MX. Potentials for prolonging shelf-life of platelets by near infrared low-level light. J Biophotonics. 2019 May;12(5):e201800390.
Zhang Q, Steensma DP, Yang J, Dong T, Wu MX. Uncoupling of CD71 shedding with mitochondrial clearance in reticulocytes in a subset of myelodysplastic syndromes. Leukemia. 2019 Jan;33(1):217-229.
Hang T, Chen HJ, Wang J, Lin DA, Wu J, Liu D, Cao Y, Yang C, Liu C, Xiao S, Gu M, Pan S, Wu MX, Xie X. Nanospikes functionalization as a universal strategy to disperse hydrophilic particles in non-polar media. Nanotechnology. 2018 May 4;29(18):185705.
Jiang H, Bian Q, Zeng W, Ren P, Sun H, Lin Z, Tang Z, Zhou X, Wang Q, Wang Y, Wang Y, Wu MX, Li X, Yu X, Huang Y. Oral delivery of Bacillus subtilis spores expressing grass carp reovirus VP4 protein produces protection against grass carp reovirus infection. Fish Shellfish Immunol. 2018 Oct 6;84:768-780.
Li P, Wang J, Cao M, Deng Q, Jiang S, Wu MX, Lu L. Topical Application of a Vitamin A Derivative and Its Combination With Non-ablative Fractional Laser Potentiates Cutaneous Influenza Vaccination. Front Microbiol. 2018 Oct 30;9:2570. PMCID: PMC6218415
Lu M, Dai T, Murray CK, Wu MX. Bactericidal Property of Oregano Oil Against Multidrug-Resistant Clinical Isolates. Front Microbiol. 2018 Oct 5;9:2329. PMCID: PMC6182053
Shahid M, Hermes EL, Chandra D, Tauseef M, Siddiqui MR, Faridi MH, Wu MX. Emerging Potential of Immediate Early Response Gene X-1 in Cardiovascular and Metabolic Diseases. J Am Heart Assoc. 2018 Nov 6;7(21):e009261. No abstract available. PMCID: PMC6404175
Wang J, Chen HJ, Hang T, Yu Y, Liu G, He G, Xiao S, Yang BR, Yang C, Liu F, Tao J, Wu MX, Xie X. Physical activation of innate immunity by spiky particles. Nat Nanotechnol. 2018 Nov;13(11):1078-1086.
Zhang P, Wu MX. A clinical review of phototherapy for psoriasis. Lasers Med Sci. 2018 Jan;33(1):173-180. PMCID: PMC5756569
Zhang Q, Steensma DP, Yang J, Dong T, Wu MX. Uncoupling of CD71 shedding with mitochondrial clearance in reticulocytes in a subset of myelodysplastic syndromes. Leukemia. 2018 Jul 26. [Epub ahead of print]
Zhang Q, Lu M, Wu MX. Potentials for Prolonging Shelf-Life of Platelets by Near Infrared Low-Level Light. J Biophotonics. 2018 Dec 18:e201800390. [Epub ahead of print]
Cao Y, Kakar P, Hossen MN, Wu MX, Chen X. Sustained epidermal powder drug delivery via skin microchannels. J Control Release. 2017 Mar 10;249:94-102. PMCID: PMC5377446
Chen F, Yan Q, Yu Y, Wu MX. BCG vaccine powder-laden and dissolvable microneedle arrays for lesion-free vaccination. J Control Release. 2017 Jun 10;255:36-44. PMCID: PMC6091871
Xie X, Pascual C, Lieu C, Oh S, Wang J, Zou B, Xie J, Li Z, Xie J, Yeomans DC, Wu MX, Xie XS. Analgesic Microneedle Patch for Neuropathic Pain Therapy. ACS Nano. 2017 Jan 24;11(1):395-406.
Dong T, Zhi L, Bhayana B, Wu MX. Cortisol-induced immune suppression by a blockade of lymphocyte egress in traumatic brain injury. J Neuroinflammation. 2016 Aug 25;13(1):197. PMCID: PMC5000452
Jia F, Liu S, Wu MX, Chen X. Micro-fractional Epidermal Powder Delivery for Skin Vaccination. Methods Mol Biol. 2016;1404:715-23.
Kumar MN, Zhou C, Wu MX. Laser-facilitated epicutaneous immunotherapy to IgE-mediated allergy. J Control Release. 2016 Aug 10;235:82-90.
Mao Z, Wu JH, Dong T, Wu MX. Additive enhancement of wound healing in diabetic mice by low level light and topical CoQ10. Sci Rep. 2016 Feb 2;6:20084. PMCID: PMC4735721
Shahid M, Spagnolli E, Ernande L, Thoonen R, Kolodziej SA, Leyton PA, Cheng J, Tainsh RE, Mayeur C, Rhee DK, Wu MX, Scherrer-Crosbie M, Buys ES, Zapol WM, Bloch KD, Bloch DB. BMP type I receptor ALK2 is required for angiotensin II-induced cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2016 Apr 15;310(8):H984-94. PMCID: PMC4867336
Shahid M, Javed AA, Chandra D, Ramsey HE, Shah D, Khan MF, Zhao L, Wu MX. IEX-1 deficiency induces browning of white adipose tissue and resists diet-induced obesity. Sci Rep. 2016 Apr 11;6:24135. PMCID: PMC4827096
Wang J, Li P, Wu MX. Natural STING agonist as an "ideal" adjuvant for cutaneous vaccination. J Invest Dermatol. 2016 Nov;136(11):2183-2191.
Wu JH, Li B, Wu MX. Laser-induced capillary leakage for blood biomarker detection and vaccine delivery via the skin. J Biophotonics. 2016 Jul;9(7):676-82. PMCID: PMC4929029
Yang J, Zhang Q, Li P, Dong T, Wu MX. Low-level light treatment ameliorates immune thrombocytopenia. Sci Rep. 2016 Nov 30;6:38238. PMCID: PMC5128784
Zhang Q, Dong T, Li P, Wu MX. Noninvasive low-level laser therapy for thrombocytopenia. Sci Transl Med. 2016 Jul 27;8(349):349ra101.
Dong T, Zhang Q, Hamblin MR, Wu MX. Low-level light in combination with metabolic modulators for effective therapy of injured brain. J Cereb Blood Flow Metab. 2015 Sep;35(9):1435-44. PMCID: PMC4640344
Li B, Wang J, Yang SY, Zhou C, Wu MX. Sample-free quantification of blood biomarkers via laser-treated skin. Biomaterials. 2015 Aug;59:30-8. Epub 2015 May 15. PMCID: PMC4467690
Ramsey H, Zhang Q, Wu MX. Mitoquinone restores platelet production in irradiation-induced thrombocytopenia. Platelets. 2015; 26(5): 459–466. PMCID: PMC4382457
Wang J, Li B, Wu MX. Effective and lesion-free cutaneous influenza vaccination. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5005-10. PMCID: PMC4413338
Zhou C, Chen X, Zhang Q, Wang J, Wu MX. Laser mimicking mosquito bites for skin delivery of malaria sporozoite vaccines. J Control Release. 2015 Apr 28;204:30-7. PMCID: PMC4394600
Chen X, Kositratna G, Zhou C, Manstein D, Wu MX. Micro-fractional epidermal powder delivery for improved skin vaccination. J Control Release. 2014 Aug 15;192C:310-316. PMCID: PMC4171958
Ramsey H, Zhang Q, Brown DE, Steensma DP, Lin CP, Wu MX. Stress-induced hematopoietic failure in the absence of immediate early response gene X-1. Haematologica. 2014 Feb;99(2):282-91. PMCID: PMC3912958
Ramsey H, Wu MX. Mitochondrial anti-oxidant protects IEX-1 deficient mice from organ damage during endotoxemia. Int Immunopharmacol. 2014 Dec;23(2):658-63. PMCID: PMC4394602
Zhang Q, Zhou C, Hamblin MR, Wu MX. Low-level laser therapy effectively prevents secondary brain injury induced by immediate early responsive gene X-1 deficiency. J Cereb Blood Flow Metab. 2014 Aug;34(8):1391-401. PMCID: PMC4126101
Wang J, Shah D, Chen X, Anderson RR, Wu MX. A micro-sterile inflammation array as an adjuvant for influenza vaccines. Nat Commun. 2014 Jul 18;5:4447. PMCID: PMC4391636
Chen X, Wang J, Shah D, Wu MX. An update on the use of laser technology in skin vaccination. Expert Rev Vaccines. 2013 Nov;12(11):1313-23.
Han L, Zhang X, Geng L, Li M, Zhang Y, Wu MX. The expression of immediate early response gene X-1 in preeclampsia placenta and its pro-apoptotic role in preeclampsia. Hypertens Pregnancy. 2013 May;32(2):157-68.
Shah D, Sah S, Wanchu A, Wu MX, Bhatnagar A. Altered redox state and apoptosis in the pathogenesis of systemic lupus erythematosus. Immunobiology. 2013 Apr;218(4):620-7.
Wu MX, Ustyugova IV, Han L, Akilov OE. Immediate early response gene X-1, a potential prognostic biomarker in cancers. Expert Opin Ther Targets. 2013 May;17(5):593-606.
Akilov OE, Wu MX, Ustyugova IV, Falo LD Jr, Geskin LJ. Resistance of Sézary cells to TNF-α-induced apoptosis is mediated in part by a loss of TNFR1 and a high level of the IER3 expression. Exp Dermatol. 2012 Apr;21(4):287-92. PMCID:PMC3306129
Chen X, Pravetoni M, Bhayana B, Pentel PR, Wu MX. High immunogenicity of nicotine vaccines obtained by intradermal delivery with safe adjuvants. Vaccine. 2012 Dec 17;31(1):159-64. PMCID:PMC3557791
Chen X, Shah D, Kositratna G, Manstein D, Anderson RR, Wu MX. Facilitation of transcutaneous drug delivery and vaccine immunization by a safe laser technology. J Control Release. 2012 Apr 10;159(1):43-51. PMCID:PMC3322279
Chen X, Wu MX. How effective could laser-based approaches be in assisting dendritic cell immunotherapy? Immunotherapy. 2012 Oct;4(10):983-5.
Chen X, Zeng Q, Wu MX. Improved efficacy of dendritic cell-based immunotherapy by cutaneous laser illumination. Clin Cancer Res. 2012 Apr 15;18(8):2240-9. PMCID:PMC3328606
Ustyugova IV, Zhi L, Abramowitz J, Birnbaumer L, Wu MX. IEX-1 deficiency protects against colonic cancer. Mol Cancer Res. 2012 Jun;10(6):760-7. PMCID:PMC3465947
Ustyugova IV, Zhi L, Wu MX. Reciprocal regulation of the survival and apoptosis of Th17 and Th1 cells in the colon. Inflamm Bowel Dis. 2012 Feb;18(2):333-43.
Zhi L, Ustyugova IV, Chen X, Zhang Q, Wu MX. Enhanced Th17 Differentiation and Aggravated Arthritis in IEX-1-Deficient Mice by Mitochondrial Reactive Oxygen Species-Mediated Signaling. J Immunol. 2012 Aug 15;189(4):1639-47. PMCID:PMC3440304
Akilov O, Wu MX, Jin Y, Zhou Z, Geskin L, Falo LD Jr, Hasan T. Vaccination with Photodynamic Therapy-Treated Macrophages Induces Highly Suppressive T Regulatory Cells. Photodermatology, Photoimmunology & Photomedicine. 2011 Apr;27(2):97-107.
Chen X, Wu MX. Laser vaccine adjuvant for cutaneous immunization. Expert Rev Vaccines. 2011 Oct;10(10):1397-403. PMCID: PMC3250349
Han L, Geng L, Liu X, Shi H, He W, Wu MX. Clinical significance of IEX-1 expression in ovarian carcinoma. Ultrastruct Pathol. 2011 Dec;35(6):260-6.
Pitsillides CM, Runnels JM, Spencer JA, Zhi L, Wu MX, Lin CP. Cell labeling approaches for fluorescence-based in vivo flow cytometry. Cytometry A. 2011 Oct;79(10):758-65.
Zhi L, Kim P, Thompson BD, Pitsillides C, Bankovich AJ, Yun SH, Lin CP, Cyster JG, Wu MX. FTY720 blocks egress of T cells in part by abrogation of their adhesion on the lymph node sinus. J Immunol. 2011 Sep 1;187(5):2244-51. Epub 2011 Jul 25. PMCID: PMC3167479
Chen X, Kim P, Farinelli B, Doukas A, Yun SH, Gelfand JA, Anderson RR, Wu MX. A Novel laser vaccine adjuvant increases the motility of antigen presenting cells. PLoS One. 2010 Oct 29;5(10):e13776. PMCID: PMC2966445
Mroz P, Szokalska A, Wu MX, Hamblin MR. Photodynamic Therapy of Tumors Can Lead to Development of Systemic Antigen-Specific Immune Response. PLoS ONE 2010, 5(12): e15194. PMCID: PMC3001867
Shahid M, Shen L, Seldin DC, Lu B, Ustyugova IV, Chen X, Zapol WM, Wu MX. Impaired cAMP-mediated signaling in IEX-1 deficient vascular smooth muscle cells. Hypertension. 2010 Oct;56(4):705-12. PMCID: PMC3157252
Yu B, Shahid M, Egorina EM, Sovershaev MA, Raher MJ, Lei C, Wu MX, Bloch KD, Zapol WM. Endothelial dysfunction enhances vasoconstriction due to scavenging of nitric oxide by a hemoglobin-based oxygen carrier. Anesthesiology. 2010 Mar;112(3):586-94. PMCID: PMC2829726
Akilov OE, Ustyugova IV, Zhi L, Hasan T, Wu MX. Enhanced Susceptibility to Leishmania Infection in Resistant Mice in the Absence of Immediate Early Response Gene X-1. J Immunol. 2009 Dec 15;183(12):7994-8003.
Castaño AP, Mroz P, Wu MX, Hamblin MR. Photodynamic therapy plus low-dose cyclophosphamide generates antitumor immunity in a mouse model. Proc Natl Acad Sci U S A 2008 Apr 8;105(14):5495-500. PMCID: PMC2291083
Jin Y, Thompson BD, Zhou ZY, Fu Y, Birnbaumer L, Wu MX. Reciprocal effects of Gai2 and Gai3 on murine graft-versus-host disease. Eur J Immunol 2008;38:1988-1998. PMCID: PMC2586968
Jin YZ, Wu MX. Requirement of Gαi in thymic joming and early T cell development. Mol Immunol 2008 Jul;45(12):3401-10. PMCID: PMC2495766
Jin YZ, Thompson BD, Zhou ZY, Fu Y, Birnbaumer L, Wu MX. Reciprocal function of Galphai2 and Galphai3 in graft-versus-host disease. Eur J Immunol 2008 Jul;38(7):1988-98. PMCID: PMC2586968
Thompson BD, Jin Y, Wu KH, Colvin RA, Luster AD, Birnbaumer L, Wu MX. Inhibition of Gai2 Activation by Gai3 in CXCR3-mediated Signaling. J Biol Chem 2007;282(13):9547-55. PMCID: PMC2366813
Shen L, Guo J, Santos-Berrios C, Wu MX. Distinct domains for anti- and pro-apoptotic activities of IEX-1. J Biol Chem 2006;281(22):15304-11.
Wu JY, Jin YZ, Edwards RA, Zhang Y, Finegold MJ, Wu MX. Impaired TGF-beta responses in peripheral T cells of Gαi2-/-mice. J Immunol 2005;174(10):6122-8.
Zhang Y, Finegold MJ, Jin Y, Wu MX. Accelerated transition from double-positive to single-positive thymocytes in Gαi2-deficient mice. Int Immunol 2005;17(3):233-43.
