Evans Lab

Hwang W, McPartland T, Jeong S, Evans CL

A robust method for autofluorescence-free immunofluorescence using high-speed fluorescence lifetime imaging microscopy.
Sci Rep. 2025;15(1):5503 - PMID: 39953137 - PMCID: PMC11828918 - DOI: 10.1038/s41598-025-89142-6

Hwang W, McPartland T, Raymond T, Han M, Jeong S, Evans CL

Quantitative investigation of photobleaching-based autofluorescence suppression in formalin-fixed paraffin-embedded human tissue.
Biomed Opt Express. 2025;16(2):553-565 - PMID: 39958863 - PMCID: PMC11828445 - DOI: 10.1364/BOE.547033

Nguyen JQ, Goss A, Keshishian H, Berchard F, Parks J, Evans C

TiMON: a real-time integrated monitor for improving the placement and wear of emergency tourniquets.
BMC Emerg Med. 2025;25(1):4 - PMID: 39762798 - PMCID: PMC11705624 - DOI: 10.1186/s12873-024-01169-6

Berkane Y, Cascales JP, Roussakis E, Lellouch AG, Slade J, Bertheuil N, Randolph MA, Cetrulo CL, Evans CL, Uygun K

Continuous oxygen monitoring to enhance ex-vivo organ machine perfusion and reconstructive surgery.
Biosens Bioelectron. 2024;262:116549 - PMID: 38971037 - PMCID: PMC11288283 - DOI: 10.1016/j.bios.2024.116549

Roussakis E, Cascales JP, Yoeli D, Cralley A, Goss A, Wiatrowski A, Carvalho M, Moore HB, Moore EE, Huang CA, Evans CL

Versatile, in-line optical oxygen tension sensors for continuous monitoring during ex vivo kidney perfusion.
Sens Diagn. 2024;3(6):1014-1019 - PMID: 38882471 - PMCID: PMC11170683 - DOI: 10.1039/d3sd00240c

Hwang W, Raymond T, McPartland T, Jeong S, Evans CL

Fluorescence Lifetime Multiplexing (FLEX) for simultaneous high dimensional spatial biology in 3D.
Commun Biol. 2024;7(1):1012 - PMID: 39154126 - PMCID: PMC11330493 - DOI: 10.1038/s42003-024-06702-8

Blades CM, Dumanian ZP, Wang Y, Wang Z, Li B, Washington KM, Slade JB, Evans CL, Arrowsmith P, Farkash EA, Yu JW, Greyson MA, Huang CA, Navarro-Alvarez N, Mathes DW

Autologous porcine VRAM flap model for VCA research.
Front Transplant. 2024;3:1504959 - PMID: 39712036 - PMCID: PMC11659244 - DOI: 10.3389/frtra.2024.1504959

Luna SK, Maciel Tabosa MA, Khoo TC, Evans CL

Developing a method for the study of perfusion effects in topical product pharmacokinetics.
Eur J Pharm Sci. 2024;205:106975 - PMID: 39631633 - DOI: 10.1016/j.ejps.2024.106975

Iliopoulos F, Tu D, Pence IJ, Li X, Ghosh P, Luke MC, Raney SG, Rantou E, Evans CL

Determining topical product bioequivalence with stimulated Raman scattering microscopy.
J Control Release. 2024;367:864-876 - PMID: 38346503 - DOI: 10.1016/j.jconrel.2024.02.010

Wei Y, Pence IJ, Wiatrowski A, Slade JB, Evans CL

Quantitative analysis of drug tablet aging by fast hyper-spectral stimulated Raman scattering microscopy.
Analyst. 2024;149(5):1436-1446 - PMID: 38050860 - DOI: 10.1039/d3an01527k

Witthauer L, Roussakis E, Cascales JP, Goss A, Li X, Cralley A, Yoeli D, Moore HB, Wang Z, Wang Y, Li B, Huang CA, Moore EE, Evans CL

Development and in-vivo validation of a portable phosphorescence lifetime-based fiber-optic oxygen sensor.
Sci Rep. 2023;13(1):14782 - PMID: 37679415 - PMCID: PMC10484954 - DOI: 10.1038/s41598-023-41917-5

Cascales JP, Draghici AE, Keshishian H, Taylor JA, Evans CL

Calculation of Tissue Oxygenation via an Inverse Boundary Problem for Transcutaneous Oxygenation Wearable Applications.
ACS Meas Sci Au. 2023;3(4):269-276 - PMID: 37600461 - PMCID: PMC10436371 - DOI: 10.1021/acsmeasuresciau.3c00013

Greenfield DA, Feizpour A, Evans CL

Quantifying Inflammatory Response and Drug-Aided Resolution in an Atopic Dermatitis Model with Deep Learning.
J Invest Dermatol. 2023;143(8):1430-1438.e4 - PMID: 36804151 - PMCID: PMC11586883 - DOI: 10.1016/j.jid.2023.01.026

Marks HL, Cook K, Roussakis E, Cascales JP, Korunes-Miller JT, Grinstaff MW, Evans CL

Quantitative Luminescence Photography of a Swellable Hydrogel Dressing with a Traffic-Light Response to Oxygen.
Adv Healthc Mater. 2022;11(10):e2101605 - PMID: 35120400 - DOI: 10.1002/adhm.202101605

Moradi Tuchayi S, Wang Y, Khodorova A, Pence IJ, Stemmer-Rachamimov A, Evans CL, Anderson RR, Garibyan L

Fast-acting and injectable cryoneurolysis device.
Sci Rep. 2022;12(1):19891 - PMID: 36400878 - PMCID: PMC9674623 - DOI: 10.1038/s41598-022-24178-6

Cascales JP, Li X, Roussakis E, Evans CL

A Patient-Ready Wearable Transcutaneous CO2 Sensor.
Biosensors (Basel). 2022;12(5):ePub - PMID: 35624634 - PMCID: PMC9138690 - DOI: 10.3390/bios12050333

Lakatos K, Gonzalez G, Hoballah J, Brooker J, Jeong S, Evans C, Krauledat P, Hansen WP, Elias KM, Patankar M, Fulop V, Konstantinopoulos PA, Cramer DW

Application of a novel microscopic technique for quantifying CA125 binding to circulating mononuclear cells in longitudinal specimens during treatment for ovarian cancer.
J Ovarian Res. 2022;15(1):28 - PMID: 35219339 - PMCID: PMC8881808 - DOI: 10.1186/s13048-022-00957-7

Muller M, Cascales JP, Marks HL, Wang-Evers M, Manstein D, Evans CL

Phosphorescent Microneedle Array for the Measurement of Oxygen Partial Pressure in Tissue.
ACS Sens. 2022;7(11):3440-3449 - PMID: 36305608 - DOI: 10.1021/acssensors.2c01775

Moradi Tuchayi S, Wang Y, Pence IJ, Fast A, Stemmer-Rachamimov A, Evans CL, Anderson RR, Garibyan L

Full Recovery after Multiple Treatments with Injectable Ice Slurry.
J Pain Res. 2022;15:2905-2910 - PMID: 36132994 - PMCID: PMC9482954 - DOI: 10.2147/JPR.S373421

Waldman A, Evans CL

Future Potential of 2-Photon Fluorescence Microscopy in Mohs and General Dermatology Practice.
JAMA Dermatol. 2022;158(10):1123-1124 - PMID: 36069853 - DOI: 10.1001/jamadermatol.2022.3510

Moradi Tuchayi S, Wang Y, Khodorova A, Pence IJ, Evans CL, Anderson RR, Lerner EA, Woolf CJ, Garibyan L

Cryoneurolysis with Injectable Ice Slurry Modulates Mechanical Skin Pain.
J Invest Dermatol. 2022;143(1):134-141.e1 - PMID: 35985498 - DOI: 10.1016/j.jid.2022.07.018

Allouche J, Rachmin I, Adhikari K, Pardo LM, Lee JH, McConnell AM, Kato S, Fan S, Kawakami A, Suita Y, Wakamatsu K, Igras V, Zhang J, Navarro PP, Lugo CM, Noonan HR, Christie KA, Itin K, Mujahid N, Lo JA, Won CH, Evans CL, Weng QY, Wang H, Osseiran S, Lovas A, Németh I, Cozzio A, Navarini AA, Hsiao JJ, Nguyen N, Kemény LV, Iliopoulos O, Berking C, Ruzicka T, Gonzalez-José R, Bortolini MC, Canizales-Quinteros S, Acuna-Alonso V, Gallo C, Poletti G, Bedoya G, Rothhammer F, Ito S, Schiaffino MV, Chao LH, Kleinstiver BP, Tishkoff S, Zon LI, Nijsten T, Ruiz-Linares A, Fisher DE, Roider E

NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism.
Cell. 2021;184(16):4268-4283.e20 - PMID: 34233163 - PMCID: PMC8349839 - DOI: 10.1016/j.cell.2021.06.022

Kuzma BA, Pence IJ, Greenfield DA, Ho A, Evans CL

Visualizing and quantifying antimicrobial drug distribution in tissue.
Adv Drug Deliv Rev. 2021;177:113942 - PMID: 34437983 - DOI: 10.1016/j.addr.2021.113942

Gonzalez G, Lakatos K, Hoballah J, Fritz-Klaus R, Al-Johani L, Brooker J, Jeong S, Evans CL, Krauledat P, Cramer DW, Hoffman RA, Hansen WP, Patankar MS

Characterization of Cell-Bound CA125 on Immune Cell Subtypes of Ovarian Cancer Patients Using a Novel Imaging Platform.
Cancers (Basel). 2021;13(9):ePub - PMID: 33922973 - PMCID: PMC8123299 - DOI: 10.3390/cancers13092072

Peng F, Jeong S, Ho A, Evans CL

Recent progress in plasmonic nanoparticle-based biomarker detection and cytometry for the study of central nervous system disorders.
Cytometry A. 2021;99(11):1067-1078 - PMID: 34328262 - DOI: 10.1002/cyto.a.24489

Pence IJ, Kuzma BA, Brinkmann M, Hellwig T, Evans CL

Multi-window sparse spectral sampling stimulated Raman scattering microscopy.
Biomed Opt Express. 2021;12(10):6095-6114 - PMID: 34745724 - PMCID: PMC8547998 - DOI: 10.1364/BOE.432177

Kuzma BA, Pence IJ, Ho A, Evans CL

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging.
J Vis Exp. 2021;(177):ePub - PMID: 34897272 - DOI: 10.3791/63264

Pence IJ, Evans CL

Translational biophotonics with Raman imaging: clinical applications and beyond.
Analyst. 2021;146(21):6379-6393 - PMID: 34596653 - PMCID: PMC8543123 - DOI: 10.1039/d1an00954k

Kawai K, Stowe AM, Evans CL, Serbulescu RF, Hanidziar D, Lee KM, Tedder TF, Poznansky MC

The 2021 FASEB virtual Catalyst Conference on B Cells in Injury and Regeneration, April 21, 2021.
FASEB J. 2021;35(8):e21744 - PMID: 34224602 - DOI: 10.1096/fj.202100963

Marks H, Bucknor A, Roussakis E, Nowell N, Kamali P, Cascales JP, Kazei D, Lin SJ, Evans CL

A paintable phosphorescent bandage for postoperative tissue oxygen assessment in DIEP flap reconstruction.
Sci Adv. 2020;6(51):ePub - PMID: 33355131 - PMCID: PMC11206211 - DOI: 10.1126/sciadv.abd1061

Pena AM, Chen X, Pence IJ, Bornschlogl T, Jeong S, Gregoire S, Luengo GS, Hallegot P, Obeidy P, Feizpour A, Chan KF, Evans CL

Imaging and quantifying drug delivery in skin - Part 2: Fluorescence andvibrational spectroscopic imaging methods.
Adv Drug Deliv Rev. 2020;153:147-168 - PMID: 32217069 - PMCID: PMC7483684 - DOI: 10.1016/j.addr.2020.03.003

Nguyen JQ, Marks HL, Everett T, Haire T, Carlsson A, Chan R, Evans CL

Early visualization of skin burn severity using a topically applied dye-loaded liquid bandage.
Sci Rep. 2020;10(1):9314 - PMID: 32518260 - PMCID: PMC7283312 - DOI: 10.1038/s41598-020-65747-x

Jeong S, Greenfield DA, Hermsmeier M, Yamamoto A, Chen X, Chan KF, Evans CL

Time-resolved fluorescence microscopy with phasor analysis for visualizing multicomponent topical drug distribution within human skin.
Sci Rep. 2020;10(1):5360 - PMID: 32210332 - PMCID: PMC7093415 - DOI: 10.1038/s41598-020-62406-z

Cascales JP, Roussakis E, Witthauer L, Goss A, Li X, Chen Y, Marks HL, Evans CL

Wearable device for remote monitoring of transcutaneous tissue oxygenation.
Biomed Opt Express. 2020;11(12):6989-7002 - PMID: 33408975 - PMCID: PMC7747925 - DOI: 10.1364/BOE.408850

Evans CL, Hermsmeier M, Yamamoto A, Chan KF

Visualizing topical drug uptake with conventional fluorescence microscopy and deep learning.
Biomed Opt Express. 2020;11(12):6864-6880 - PMID: 33408967 - PMCID: PMC7747892 - DOI: 10.1364/BOE.405502

Ochocinska MJ, Spitalnik SL, Abuhamad A, Bennett-Guerrero E, Carlo WA, Cherukuri M, Doctor A, Dzik W, Evans CL, Forzani E, Kuppusamy P, Moan NL, Li L, Luban N, Mohandas N, Patel RM, Roback J, Swartz H, Textor S, Vinogradov S, Wang LV, Wisniewski N, Glynn S

NIH Workshop 2018: Towards Minimally Invasive or Noninvasive Approaches to Assess Tissue Oxygenation Pre- and Post-transfusion.
Transfus Med Rev. 2020;35(1):46-55 - PMID: 33353783 - PMCID: PMC8325696 - DOI: 10.1016/j.tmrv.2020.12.003

Witthauer L, Cascales JP, Roussakis E, Li X, Goss A, Chen Y, Evans CL

Portable Oxygen-Sensing Device for the Improved Assessment of Compartment Syndrome and other Hypoxia-Related Conditions.
ACS Sens. 2020;6(1):43-53 - PMID: 33325684 - DOI: 10.1021/acssensors.0c01686

Jeong S, Gonzalez G, Ho A, Nowell N, Austin LA, Hoballah J, Mubarak F, Kapur A, Patankar MS, Cramer DW, Krauledat P, Hansen WP, Evans CL

Plasmonic Nanoparticle-Based Digital Cytometry to Quantify MUC16 Binding on the Surface of Leukocytes in Ovarian Cancer.
ACS Sens. 2020;5(9):2772-2782 - PMID: 32847358 - PMCID: PMC7871419 - DOI: 10.1021/acssensors.0c00567

Goralnick E, Ezeibe C, Chaudhary MA, McCarty J, Herrera-Escobar JP, Andriotti T, de Jager E, Ospina-Delgado D, Goolsby C, Hunt R, Weissman JS, Haider A, Jacobs L, Stop the Bleed National Research Agenda Consensus Conference Working Group, Andrade E, Brown J, Bulger EM, Butler FK, Callaway D, Caterson EJ, Choudhry NK, Davis MR, Eastman A, Eastridge BJ, Epstein JL, Evans CL, Gausche-Hill M, Gestring ML, Goldberg SA, Hanfling D, Holcomb JB, Jonson CO, King DR, Kivlehan S, Kotwal RS, Krohmer JR, Levy-Carrick N, Levy M, Meléndez Lugo JJ, Mooney DP, Neal MD, Niskanen R, O'Neill P, Park H, Pons PT, Prytz E, Rasmussen TE, Remley MA, Riviello R, Salim A, Shackelfold S, Smith ER, Stewart RM, Swaroop M, Ward K, Uribe-Leitz T, Jarman MP, Ortega G

Defining a Research Agenda for Layperson Prehospital Hemorrhage Control: A Consensus Statement.
JAMA Netw Open. 2020;3(7):e209393 - PMID: 32663307 - DOI: 10.1001/jamanetworkopen.2020.9393

Roussakis E, Cascales JP, Marks HL, Li X, Grinstaff M, Evans CL

Humidity-Insensitive Tissue Oxygen Tension Sensing for Wearable Devices†.
Photochem Photobiol. 2020;96(2):373-379 - PMID: 31869435 - DOI: 10.1111/php.13198

Garibyan L, Moradi Tuchayi S, Wang Y, Khodorova A, Stemmer-Rachamimov A, Purschke M, Osseiran S, Evans CL, Mao J, Strichartz G, Anderson RR

Neural Selective Cryoneurolysis with Ice Slurry Injection in a Rat Model.
Anesthesiology. 2020;133(1):185-194 - PMID: 31977524 - PMCID: PMC7299828 - DOI: 10.1097/ALN.0000000000003124

Feizpour A, Marstrand T, Bastholm L, Eirefelt S, Evans CL

Label-Free Quantification of Pharmacokinetics in Skin with Stimulated Raman Scattering Microscopy and Deep Learning.
J Invest Dermatol. 2020;141(2):395-403 - PMID: 32710899 - DOI: 10.1016/j.jid.2020.06.027

Gregoire S, Luengo GS, Hallegot P, Pena AM, Chen X, Bornschlogl T, Chan KF, Pence I, Obeidy P, Feizpour A, Jeong S, Evans CL

Imaging and quantifying drug delivery in skin - Part 1: Autoradiography and mass spectrometry imaging.
Adv Drug Deliv Rev. 2019;153:137-146 - PMID: 31778729 - DOI: 10.1016/j.addr.2019.11.004

Katagiri W, Lee JH, Tetrault MA, Kang H, Jeong S, Evans CL, Yokomizo S, Santos S, Jones C, Hu S, Fakhri GE, Tsukada K, Choi HS, Kashiwagi S

Real-Time Imaging of Vaccine Biodistribution Using Zwitterionic NIR Nanoparticles.
Adv Healthc Mater. 2019;8(15):e1900035 - PMID: 31165556 - PMCID: PMC6687515 - DOI: 10.1002/adhm.201900035

Roussakis E, Ortines RV, Pinsker BL, Mooers CT, Evans CL, Miller LS, Calderon-Colon X

Theranostic biocomposite scaffold membrane.
Biomaterials. 2019;212:17-27 - PMID: 31100480 - DOI: 10.1016/j.biomaterials.2019.05.007

Osseiran S, Austin LA, Cannon TM, Yan C, Langenau DM, Evans CL

Longitudinal monitoring of cancer cell subpopulations in monolayers, 3D spheroids, and xenografts using the photoconvertible dye DiR.
Sci Rep. 2019;9(1):5713 - PMID: 30952965 - PMCID: PMC6450962 - DOI: 10.1038/s41598-019-42165-2

Brinkmann M, Fast A, Hellwig T, Pence I, Evans CL, Fallnich C

Portable all-fiber dual-output widely tunable light source for coherent Raman imaging.
Biomed Opt Express. 2019;10(9):4437-4449 - PMID: 31565500 - PMCID: PMC6757451 - DOI: 10.1364/BOE.10.004437

Li Z, Marks H, Evans CL, Apiou-Sbirlea G

Sensing, monitoring, and release of therapeutics: the translational journey of next generation bandages (Erratum).
J Biomed Opt. 2019;24(2):1 - PMID: 30756529 - PMCID: PMC6988180 - DOI: 10.1117/1.JBO.24.2.029802

Gonzalez G, Evans CL

Biomedical Image Processing with Containers and Deep Learning: An Automated Analysis Pipeline: Data architecture, artificial intelligence, automated processing, containerization, and clusters orchestration ease the transition from data acquisition to insights in medium-to-large datasets.
Bioessays. 2019;41(6):e1900004 - PMID: 31094000 - PMCID: PMC6538271 - DOI: 10.1002/bies.201900004

Gkikas M, Peponis T, Mesar T, Hong C, Avery RK, Roussakis E, Yoo HJ, Parakh A, Patino M, Sahani DV, Watkins MT, Oklu R, Evans CL, Albadawi H, Velmahos G, Olsen BD

Systemically Administered Hemostatic Nanoparticles for Identification and Treatment of Internal Bleeding.
ACS Biomater Sci Eng. 2019;5(5):2563-2576 - PMID: 33405762 - DOI: 10.1021/acsbiomaterials.9b00054

Evers M, Salma N, Osseiran S, Casper M, Birngruber R, Evans CL, Manstein D

Enhanced quantification of metabolic activity for individual adipocytes by label-free FLIM.
Sci Rep. 2018;8(1):8757 - PMID: 29884881 - PMCID: PMC5993796 - DOI: 10.1038/s41598-018-27093-x

Osseiran S, Cruz JD, Jeong S, Wang H, Fthenakis C, Evans CL

Characterizing stratum corneum structure, barrier function, and chemical content of human skin with coherent Raman scattering imaging.
Biomed Opt Express. 2018;9(12):6425-6443 - PMID: 31065440 - PMCID: PMC6490993 - DOI: 10.1364/BOE.9.006425

Hermsmeier M, Jeong S, Yamamoto A, Chen X, Nagavarapu U, Evans CL, Chan KF

Characterization of human cutaneous tissue autofluorescence: implications in topical drug delivery studies with fluorescence microscopy.
Biomed Opt Express. 2018;9(11):5400-5418 - PMID: 30460136 - PMCID: PMC6238944 - DOI: 10.1364/BOE.9.005400

Jeong S, Hermsmeier M, Osseiran S, Yamamoto A, Nagavarapu U, Chan KF, Evans CL

Visualization of drug distribution of a topical minocycline gel in human facial skin.
Biomed Opt Express. 2018;9(7):3434-3448 - PMID: 29984108 - PMCID: PMC6033575 - DOI: 10.1364/BOE.9.003434

Li Z, Marks H, Evans C, Apiou-Sbirlea G

Sensing, monitoring, and release of therapeutics: the translational journey of next generation bandages.
J Biomed Opt. 2018;24(2):1-9 - PMID: 30592189 - PMCID: PMC6987519 - DOI: 10.1117/1.JBO.24.2.021201

Evans CL

Nonlinear Optical Microscopy for Melanoma: Challenges, Tools and Opportunities.
Photochem Photobiol. 2018;94(4):624-632 - PMID: 29485199 - DOI: 10.1111/php.12916

Yamada M, Tayeb H, Wang H, Dang N, Mohammed YH, Osseiran S, Belt PJ, Roberts MS, Evans CL, Sainsbury F, Prow TW

Using elongated microparticles to enhance tailorable nanoemulsion delivery in excised human skin and volunteers.
J Control Release. 2018;288:264-276 - PMID: 30227159 - PMCID: PMC7050638 - DOI: 10.1016/j.jconrel.2018.09.012

Baugh LM, Liu Z, Quinn KP, Osseiran S, Evans CL, Huggins GS, Hinds PW, Black LD, Georgakoudi I

Non-destructive two-photon excited fluorescence imaging identifies early nodules in calcific aortic-valve disease.
Nat Biomed Eng. 2017;1(11):914-924 - PMID: 29456878 - PMCID: PMC5811202 - DOI: 10.1038/s41551-017-0152-3

Evans CL

New near-infrared dyes light up deep tissue imaging.
Sci Transl Med. 2017;9(378):ePub - PMID: 28228597 - DOI: 10.1126/scitranslmed.aam6065

Evans CL

Endomicroscope sheds light on cervical tissue.
Sci Transl Med. 2017;9(372):ePub - PMID: 28077680 - DOI: 10.1126/scitranslmed.aal4989

Klein OJ, Yuan H, Nowell NH, Kaittanis C, Josephson L, Evans CL

An Integrin-Targeted, Highly Diffusive Construct for Photodynamic Therapy.
Sci Rep. 2017;7(1):13375 - PMID: 29042620 - PMCID: PMC5645319 - DOI: 10.1038/s41598-017-13803-4

Koolen PGL, Li Z, Roussakis E, Paul MA, Ibrahim AMS, Matyal R, Huang T, Evans CL, Lin SJ

Oxygen-Sensing Paint-On Bandage: Calibration of a Novel Approach in Tissue Perfusion Assessment.
Plast Reconstr Surg. 2017;140(1):89-96 - PMID: 28654595 - DOI: 10.1097/PRS.0000000000003421

Li Z, Navarro-Alvarez N, Keeley EJ, Nowell NH, Goncalves BMM, Huang CA, Evans CL

Non-invasive monitoring of skin inflammation using an oxygen-sensing paint-on bandage.
Biomed Opt Express. 2017;8(10):4640-4651 - PMID: 29082091 - PMCID: PMC5654806 - DOI: 10.1364/BOE.8.004640

Osseiran S, Roider EM, Wang H, Suita Y, Murphy M, Fisher DE, Evans CL

Non-Euclidean phasor analysis for quantification of oxidative stress in ex vivo human skin exposed to sun filters using fluorescence lifetime imaging microscopy.
J Biomed Opt. 2017;22(12):1-10 - PMID: 29222855 - PMCID: PMC5722918 - DOI: 10.1117/1.JBO.22.12.125004

Bazou D, Maimon N, Gruionu G, Grahovac J, Seano G, Liu H, Evans CL, Munn LL

Vascular beds maintain pancreatic tumour explants for ex vivo drug screening.
J Tissue Eng Regen Med. 2017;12(1):e318-e322 - PMID: 28568605 - PMCID: PMC5711628 - DOI: 10.1002/term.2481

Evans CL

Photoacoustic imaging sounds the alarm on liver fibrosis.
Sci Transl Med. 2016;8(366):366ec186 - PMID: 27881817 - DOI: 10.1126/scitranslmed.aal2794

Hung HI, Klein OJ, Peterson SW, Rokosh SR, Osseiran S, Nowell NH, Evans CL

PLGA nanoparticle encapsulation reduces toxicity while retaining the therapeutic efficacy of EtNBS-PDT in vitro.
Sci Rep. 2016;6:33234 - PMID: 27686626 - PMCID: PMC5043181 - DOI: 10.1038/srep33234

Jung Y, Klein OJ, Wang H, Evans CL

Longitudinal, label-free, quantitative tracking of cell death and viability in a 3D tumor model with OCT.
Sci Rep. 2016;6:27017 - PMID: 27248849 - PMCID: PMC4888651 - DOI: 10.1038/srep27017

Wang H, Osseiran S, Igras V, Nichols AJ, Roider EM, Pruessner J, Tsao H, Fisher DE, Evans CL

In vivo coherent Raman imaging of the melanomagenesis-associated pigment pheomelanin.
Sci Rep. 2016;6:37986 - PMID: 27892516 - PMCID: PMC5125099 - DOI: 10.1038/srep37986

Saytashev I, Glenn R, Murashova GA, Osseiran S, Spence D, Evans CL, Dantus M

Multiphoton excited hemoglobin fluorescence and third harmonic generation for non-invasive microscopy of stored blood.
Biomed Opt Express. 2016;7(9):3449-3460 - PMID: 27699111 - PMCID: PMC5030023 - DOI: 10.1364/BOE.7.003449

Apiou-Sbirlea G, Evans CL, Kelly KM, Tromberg BJ

Special Section Guest Editorial: Translational biophotonics.
J Biomed Opt. 2016;21(12):124002 - PMID: 27999859 - DOI: 10.1117/1.JBO.21.12.124002

Kessel D, Evans CL

Promotion of Proapoptotic Signals by Lysosomal Photodamage: Mechanistic Aspects and Influence of Autophagy.
Photochem Photobiol. 2016;92(4):620-3 - PMID: 27096545 - PMCID: PMC4961560 - DOI: 10.1111/php.12592

Austin LA, Osseiran S, Evans CL

Raman technologies in cancer diagnostics.
Analyst. 2016;141(2):476-503 - PMID: 26539569 - DOI: 10.1039/c5an01786f

Roussakis E, Li Z, Nowell NH, Nichols AJ, Evans CL

Bright, "Clickable" Porphyrins for the Visualization of Oxygenation under Ambient Light.
Angew Chem Int Ed Engl. 2015;54(49):14728-31 - PMID: 26510549 - PMCID: PMC4715754 - DOI: 10.1002/anie.201506847

Roussakis E, Li Z, Nichols AJ, Evans CL

Oxygen-Sensing Methods in Biomedicine from the Macroscale to the Microscale.
Angew Chem Int Ed Engl. 2015;54(29):8340-62 - PMID: 26084034 - DOI: 10.1002/anie.201410646

Garibyan L, Cornelissen L, Sipprell W, Pruessner J, Elmariah S, Luo T, Lerner EA, Jung Y, Evans C, Zurakowski D, Berde CB, Rox Anderson R

Transient Alterations of Cutaneous Sensory Nerve Function by Noninvasive Cryolipolysis.
J Invest Dermatol. 2015;135(11):2623-2631 - PMID: 26099028 - PMCID: PMC4640987 - DOI: 10.1038/jid.2015.233

Ray Jalian H, Tam J, Vuong LN, Fisher J, Garibyan L, Mihm MC, Zurakowski D, Evans CL, Rox Anderson R

Selective Cryolysis of Sebaceous Glands.
J Invest Dermatol. 2015;135(9):2173-2180 - PMID: 25860384 - DOI: 10.1038/jid.2015.148

Nichols AJ, Roussakis E, Klein OJ, Evans CL

Click-assembled, oxygen-sensing nanoconjugates for depth-resolved, near-infrared imaging in a 3D cancer model.
Angew Chem Int Ed Engl. 2014;53(14):3671-4 - PMID: 24590700 - PMCID: PMC4026265 - DOI: 10.1002/anie.201311303

Jung Y, Ng JH, Keating CP, Senthil-Kumar P, Zhao J, Randolph MA, Winograd JM, Evans CL

Comprehensive evaluation of peripheral nerve regeneration in the acute healing phase using tissue clearing and optical microscopy in a rodent model.
PLoS One. 2014;9(4):e94054 - PMID: 24714405 - PMCID: PMC3979924 - DOI: 10.1371/journal.pone.0094054

Li Z, Roussakis E, Koolen PG, Ibrahim AM, Kim K, Rose LF, Wu J, Nichols AJ, Baek Y, Birngruber R, Apiou-Sbirlea G, Matyal R, Huang T, Chan R, Lin SJ, Evans CL

Non-invasive transdermal two-dimensional mapping of cutaneous oxygenation with a rapid-drying liquid bandage.
Biomed Opt Express. 2014;5(11):3748-64 - PMID: 25426308 - PMCID: PMC4242015 - DOI: 10.1364/BOE.5.003748

Jung Y, Tam J, Ray Jalian H, Rox Anderson R, Evans CL

Longitudinal, 3D in vivo imaging of sebaceous glands by coherent anti-stokes Raman scattering microscopy: normal function and response to cryotherapy.
J Invest Dermatol. 2014;135(1):39-44 - PMID: 25026458 - PMCID: PMC4268001 - DOI: 10.1038/jid.2014.293

Vecchio D, Bhayana B, Huang L, Carrasco E, Evans CL, Hamblin MR

Structure-function relationships of Nile blue (EtNBS) derivatives as antimicrobial photosensitizers.
Eur J Med Chem. 2014;75:479-491 - PMID: 24561676 - PMCID: PMC3970436 - DOI: 10.1016/j.ejmech.2014.01.064

Rowlands CJ, Wu J, Uzel SG, Klein O, Evans CL, So PT

3D-resolved targeting of photodynamic therapy using temporal focusing.
Laser Phys Lett. 2014;11(11):ePub - PMID: 25620902 - PMCID: PMC4301304 - DOI: 10.1088/1612-2011/11/11/115605

de Groot M, Evans CL, de Boer JF

Self-interference fluorescence microscopy: three dimensional fluorescence imaging without depth scanning.
Opt Express. 2012;20(14):15253-62 - PMID: 22772223 - PMCID: PMC3601652 - DOI: 10.1364/OE.20.015253

Jung Y, Nichols AJ, Klein OJ, Roussakis E, Evans CL

Label-Free, Longitudinal Visualization of PDT Response In Vitro with Optical Coherence Tomography.
Isr J Chem. 2012;52(8-9):728-744 - PMID: 23316088 - PMCID: PMC3538822 - DOI: 10.1002/ijch.201200009

Klein OJ, Bhayana B, Park YJ, Evans CL

In vitro optimization of EtNBS-PDT against hypoxic tumor environments with a tiered, high-content, 3D model optical screening platform.
Mol Pharm. 2012;9(11):3171-82 - PMID: 22946843 - PMCID: PMC3538815 - DOI: 10.1021/mp300262x

Evans CL, Abu-Yousif AO, Park YJ, Klein OJ, Celli JP, Rizvi I, Zheng X, Hasan T

Killing hypoxic cell populations in a 3D tumor model with EtNBS-PDT.
PLoS One. 2011;6(8):e23434 - PMID: 21876751 - PMCID: PMC3158086 - DOI: 10.1371/journal.pone.0023434

Nichols AJ, Evans CL

Video-rate scanning confocal microscopy and microendoscopy.
J Vis Exp. 2011;(56):ePub - PMID: 22042305 - PMCID: PMC3227211 - DOI: 10.3791/3252

Rizvi I, Celli JP, Evans CL, Abu-Yousif AO, Muzikansky A, Pogue BW, Finkelstein D, Hasan T

Synergistic enhancement of carboplatin efficacy with photodynamic therapy in a three-dimensional model for micrometastatic ovarian cancer.
Cancer Res. 2010;70(22):9319-28 - PMID: 21062986 - PMCID: PMC3057933 - DOI: 10.1158/0008-5472.CAN-10-1783

Joo C, Evans CL, Stepinac T, Hasan T, de Boer JF

Diffusive and directional intracellular dynamics measured by field-based dynamic light scattering.
Opt Express. 2010;18(3):2858-71 - PMID: 20174115 - PMCID: PMC2839546 - DOI: 10.1364/OE.18.002858

Celli JP, Rizvi I, Evans CL, Abu-Yousif AO, Hasan T

Quantitative imaging reveals heterogeneous growth dynamics and treatment-dependent residual tumor distributions in a three-dimensional ovarian cancer model.
J Biomed Opt. 2010;15(5):051603 - PMID: 21054077 - PMCID: PMC2948043 - DOI: 10.1117/1.3483903

Celli JP, Spring BQ, Rizvi I, Evans CL, Samkoe KS, Verma S, Pogue BW, Hasan T

Imaging and photodynamic therapy: mechanisms, monitoring, and optimization.
Chem Rev. 2010;110(5):2795-838 - PMID: 20353192 - PMCID: PMC2896821 - DOI: 10.1021/cr900300p

Zheng X, Sallum UW, Verma S, Athar H, Evans CL, Hasan T

Exploiting a bacterial drug-resistance mechanism: a light-activated construct for the destruction of MRSA.
Angew Chem Int Ed Engl. 2009;48(12):2148-51 - PMID: 19206126 - DOI: 10.1002/anie.200804804

Evans CL, Rizvi I, Hasan T, de Boer JF

In vitro ovarian tumor growth and treatment response dynamics visualized with time-lapse OCT imaging.
Opt Express. 2009;17(11):8892-906 - PMID: 19466138 - PMCID: PMC2836890 - DOI: 10.1364/oe.17.008892

Abu-Yousif AO, Rizvi I, Evans CL, Celli JP, Hasan T

PuraMatrix encapsulation of cancer cells.
J Vis Exp. 2009;(34):ePub - PMID: 20019656 - PMCID: PMC3152243 - DOI: 10.3791/1692

Evans CL, Xie XS

Coherent anti-stokes Raman scattering microscopy: chemical imaging for biology and medicine.
Annu Rev Anal Chem (Palo Alto Calif). 2008;1:883-909 - PMID: 20636101 - DOI: 10.1146/annurev.anchem.1.031207.112754

Evans CL, Xu X, Kesari S, Xie XS, Wong ST, Young GS

Chemically-selective imaging of brain structures with CARS microscopy.
Opt Express. 2007;15(19):12076-87 - PMID: 19547572 - DOI: 10.1364/oe.15.012076

Legare; F, Evans CL, Ganikhanov F, Xie XS

Towards CARS Endoscopy.
Opt Express. 2006;14(10):4427-32 - PMID: 19516594 - DOI: 10.1364/oe.14.004427

Ganikhanov F, Evans CL, Saar BG, Xie XS

High-sensitivity vibrational imaging with frequency modulation coherent anti-Stokes Raman scattering (FM CARS) microscopy.
Opt Lett. 2006;31(12):1872-4 - PMID: 16729099 - DOI: 10.1364/ol.31.001872

Potma EO, Evans CL, Xie XS

Heterodyne coherent anti-Stokes Raman scattering (CARS) imaging.
Opt Lett. 2006;31(2):241-3 - PMID: 16441043 - DOI: 10.1364/ol.31.000241

Kuthirummal N, Rudakov FM, Evans CL, Weber PM

Spectroscopy and femtosecond dynamics of the ring opening reaction of 1,3-cyclohexadiene.
J Chem Phys. 2006;125(13):133307 - PMID: 17029460 - DOI: 10.1063/1.2345203

Rakic B, Sagan SM, Noestheden M, Bélanger S, Nan X, Evans CL, Xie XS, Pezacki JP

Peroxisome proliferator-activated receptor alpha antagonism inhibits hepatitis C virus replication.
Chem Biol. 2006;13(1):23-30 - PMID: 16426968 - DOI: 10.1016/j.chembiol.2005.10.006

Evans CL, Potma EO, Puoris'haag M, Côté D, Lin CP, Xie XS

Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy.
Proc Natl Acad Sci U S A. 2005;102(46):16807-12 - PMID: 16263923 - PMCID: PMC1283840 - DOI: 10.1073/pnas.0508282102

Evans CL, Potma EO, Xie XS

Coherent anti-stokes raman scattering spectral interferometry: determination of the real and imaginary components of nonlinear susceptibility chi(3) for vibrational microscopy.
Opt Lett. 2004;29(24):2923-5 - PMID: 15645825 - DOI: 10.1364/ol.29.002923

Potma EO, Evans C, Xie XS, Jones RJ, Ye J

Picosecond-pulse amplification with an external passive optical cavity.
Opt Lett. 2003;28(19):1835-7 - PMID: 14514117 - DOI: 10.1364/ol.28.001835
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