The following are recent instances of the Wellman Center for Photomedicine and Wellman Center researchers being covered by the media.

National Academy of Inventors (NAI) Fellows
Congratulations to Rox Anderson, MD who has been chosen for induction into the National Academy of Inventors to the rank of NAI Fellow for 2017.

The NAI Fellows Selection Committee chose Dr. Anderson for induction as he has "demonstrated a highly prolific spirit of innovation in creating or facilitating outstanding inventions that have made a tangible impact on quality of life, economic development, and the welfare of society." The Fellows Induction Ceremony to receive this award will be held on April 5, 2018 at the Mayflower Hotel in Washington, DC.

Please see the NAI Fellows Program for more information or for the full list of current NAI Fellows.

Britton Chance Biomedical Optics Award 2018
Dr. Tayyaba Hasan has been named the 2018 recipient of the Britton Chance Biomedical Optics Award. 

The Britton Chance Biomedical Optics Award is presented in recognition of her trailblazing contributions to the field of Photodynamic Therapy and its clinical translation, her leadership and her service to the photonics community.

The award was presented to Dr. Hasan by Maryellen L. Giger, Ph.D., SPIE President, at the SPIE Photonics West meeting on January 27th in San Francisco, CA.

2018 Bullock Postdoctoral Fellowship
Congratulations to Kwon-Hyeon Kim, Ph.D. along with his mentors Andy Yun, PhD and Peng Yin, PhD as well as Matthias Müller, Ph.D. along with his mentors Martin Purschke, PhD and Kathryn D. Held, PhD on receiving the 2018 Bullock Postdoctoral Fellowship Award.

Dr. Kim's submitted title and abstract was:
Project title: Organic semiconductor micro-laser particles
The broad goal of this proposed research is to develop microscopic laser particles as novel probes in biomedical imaging and assays. The stimulated emission characteristics of laser particles are quite different from fluorescence. Their narrow linewidth (<0.5 nm) and high brightness make them attractive for multi-channel cytometry, histopathology, and deep-tissue animal imaging.
To realize lasers in small dimension, high-gain optical materials are critical. The concentra-tion quenching of organic dyes limits the maximum achievable gain coefficient to typically <100 cm-1. Here, I propose to investigate solid-state organic semiconductor gain materials.
I will investigate two candidate materials, organoboron (TPEQBN) and platinum complex (Pt(fppz)2), which I believe may avoid concentration quenching via their large steric hin-drance and stokes shifts and can produce efficient excimer emission and high quantum yield. I expect to obtain a gain coefficient of >1,000 cm-1, an order of magnitude higher than the best organic dyes known to date. Next, I will integrate the organic semiconductor gain media with dielectric micro-cavities to demonstrate laser particles with submicron sizes.
If successful, the expected results will establish organic semiconductors as promising gain materials for laser particles and will demonstrate the first submicron-laser particles ever built with such materials, which have potential as novel bright, multi-color optical probes.

Dr. Müller's submitted title and abstract was:
Project title: Targeting hypoxic cancer cells with UVC emitting nanoparticles
Cancer is a major cause of worldwide mortality. In 2012, 14 million new cancer diseases and 8 million deaths attributed to cancer occurred. Radiation therapy is the gold standard treatment for inoperable malignant tumors, which is very effective but still requires multiple treatments with surrounding tissue damage. The irradiation of normal tissue can lead to deleterious side effects such as fibrosis. One reason for the suboptimal efficacy is the heterogenicity of the tumor tissue, in particular the variation of the O2 concentration within a tumor. Hypoxic areas, mainly located towards the center of the tumor are up to 3 times more radioresistant compared to normoxic areas.
To increase the efficiency of radiation therapy, we propose combining traditional X-ray treatment with tumor-localized UVC emitting LuPO4:Pr3+ nanoparticles (NPs). Using the combined treatment, X-rays are converted by the NPs into UVC radiation inside the tumor. UVC damages the DNA via an oxygen-independent mechanism that could improve treatment efficacy. Especially within hypoxic tumor areas, an increased efficacy is expected. In addition, due to the limited penetration depth of UVC radiation, only tumor tissue will be affected by local UVC exposure, while normal surrounding tissue will be spared.
The inorganic compound LuPO4:Pr3+ is a scintillating material. Under excitation with X-rays, LuPO4:Pr3+ emits UVC radiation in the range from 225 to 290 nm in the electromagnetic spectrum. Interaction between radiation with these wavelengths and the DNA leads to the formation of cyclobutane pyrimidine dimers as well as 6-4 photoproducts and eventually to cell death. Further, absorption of X-rays by LuPO4:Pr3+ also produces lower energy X-rays and electrons with higher energy deposition rates.
The research project will focus on the application of the UV emitting NPs to prove the concept of the project idea. For this purpose, a cancer cell line will be treated with the NPs and subsequently irradiated with X-rays. After the combined treatment, the viability of the cells will be measured. In addition, the unselective toxicity of the nanoparticles will be evaluated. In a further step, the experiments will be conducted in absence of oxygen to investigate the impact of the combined treatment under hypoxic circumstances.

Congratulations to you all!